A positive feedback circuit comprising p21 and HIF-1&#945; aggravates hypoxia-induced radioresistance of glioblastoma by promoting Glut1/LDHA-mediated glycolysis.

Jin, Xiaodong; Kuang, Yanbei; Li, Linying; Li, Hongbin; Zhao, Ting; He, Yufang; Di, Cuixia; Kang, Jian; Yuan, Lingyan; Yu, Boyi; Li, Qiang

A positive feedback circuit comprising p21 and HIF-1α aggravates hypoxia-induced radioresistance of glioblastoma by promoting Glut1/LDHA-mediated glycolysis.

Jin, Xiaodong; Kuang, Yanbei; Li, Linying; Li, Hongbin; Zhao, Ting; He, Yufang; Di, Cuixia; Kang, Jian; Yuan, Lingyan; Yu, Boyi; Li, Qiang.

Afiliação

Jin X; Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.
Kuang Y; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.
Li L; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou, China.
Li H; University of Chinese Academy of Sciences, Beijing, China.
Zhao T; Lanhai Nuclear Medicine Research Center, Putian, China.
He Y; Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.
Di C; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.
Kang J; Key Laboratory of Basic Research on Heavy Ion Radiation Application in Medicine, Gansu Province, Lanzhou, China.
Yuan L; University of Chinese Academy of Sciences, Beijing, China.
Yu B; Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, China.
Li Q; Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou, China.

FASEB J ; 36(3): e22229, 2022 03.

Article em En | MEDLINE | ID: mdl-35199870

Assuntos

Neoplasias Encefálicas/metabolismo; Inibidor de Quinase Dependente de Ciclina p21/metabolismo; Glioblastoma/metabolismo; Glicólise; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Hipóxia Tumoral; Animais; Neoplasias Encefálicas/radioterapia; Linhagem Celular Tumoral; Inibidor de Quinase Dependente de Ciclina p21/genética; Retroalimentação Fisiológica; Feminino; Glioblastoma/radioterapia; Transportador de Glucose Tipo 1/metabolismo; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; L-Lactato Desidrogenase/metabolismo; Camundongos; Tolerância a Radiação

Palavras-chave

HIF-1α; glioblastoma; glycolysis; hypoxia; p21; radioresistance

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / Inibidor de Quinase Dependente de Ciclina p21 / Subunidade alfa do Fator 1 Induzível por Hipóxia / Hipóxia Tumoral / Glicólise Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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