Your browser doesn't support javascript.
loading
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death.
Van Coillie, Samya; Van San, Emily; Goetschalckx, Ines; Wiernicki, Bartosz; Mukhopadhyay, Banibrata; Tonnus, Wulf; Choi, Sze Men; Roelandt, Ria; Dumitrascu, Catalina; Lamberts, Ludwig; Dams, Geert; Weyts, Wannes; Huysentruyt, Jelle; Hassannia, Behrouz; Ingold, Irina; Lele, Suhas; Meyer, Evelyne; Berg, Maya; Seurinck, Ruth; Saeys, Yvan; Vermeulen, An; van Nuijs, Alexander L N; Conrad, Marcus; Linkermann, Andreas; Rajapurkar, Mohan; Vandenabeele, Peter; Hoste, Eric; Augustyns, Koen; Vanden Berghe, Tom.
Afiliação
  • Van Coillie S; VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Van San E; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Goetschalckx I; VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Wiernicki B; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Mukhopadhyay B; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
  • Tonnus W; VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Choi SM; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Roelandt R; Department of Nephrology, Muljibhai Patel Society for Research in Nephro-Urology, Nadiad, India.
  • Dumitrascu C; Department of Internal Medicine 3, University Hospital Carl Gustav Carus, the Technische Universität Dresden, Dresden, Germany.
  • Lamberts L; VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Dams G; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Weyts W; VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Huysentruyt J; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Hassannia B; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.
  • Ingold I; Department of Pharmaceutical Sciences, Toxicological Centre, University of Antwerp, Antwerp, Belgium.
  • Lele S; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
  • Meyer E; Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
  • Berg M; VIB-UGent Center for Medical Biotechnology, Ghent, Belgium.
  • Seurinck R; VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Saeys Y; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Vermeulen A; VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • van Nuijs ALN; Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.
  • Conrad M; Institute of Metabolism and Cell Death, Helmholtz Zentrum München, German Research Center for Environmental Health, Munich, Germany.
  • Linkermann A; Department of Medicine III, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.
  • Rajapurkar M; Department of Nephrology, Muljibhai Patel Society for Research in Nephro-Urology, Nadiad, India.
  • Vandenabeele P; Department of Pharmacology, Toxicology and Biochemistry, Ghent University, Merelbeke, Belgium.
  • Hoste E; Department of Pharmaceutical Sciences, Toxicological Centre, University of Antwerp, Antwerp, Belgium.
  • Augustyns K; VIB-UGent Center for Inflammation Research, Ghent, Belgium.
  • Vanden Berghe T; Department of Applied Mathematics, Computer Science and Statistics, Ghent University, Ghent, Belgium.
Nat Commun ; 13(1): 1046, 2022 02 24.
Article em En | MEDLINE | ID: mdl-35210435
The most common cause of death in the intensive care unit (ICU) is the development of multiorgan dysfunction syndrome (MODS). Besides life-supporting treatments, no cure exists, and its mechanisms are still poorly understood. Catalytic iron is associated with ICU mortality and is known to cause free radical-mediated cellular toxicity. It is thought to induce excessive lipid peroxidation, the main characteristic of an iron-dependent type of cell death conceptualized as ferroptosis. Here we show that the severity of multiorgan dysfunction and the probability of death are indeed associated with plasma catalytic iron and lipid peroxidation. Transgenic approaches underscore the role of ferroptosis in iron-induced multiorgan dysfunction. Blocking lipid peroxidation with our highly soluble ferrostatin-analogue protects mice from injury and death in experimental non-septic multiorgan dysfunction, but not in sepsis-induced multiorgan dysfunction. The limitations of the experimental mice models to mimic the complexity of clinical MODS warrant further preclinical testing. In conclusion, our data suggest ferroptosis targeting as possible treatment option for a stratifiable subset of MODS patients.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ferroptose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ferroptose Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article