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Immunohistochemical analysis of pyroptosis-related protein expression in IgG4-related sialadenitis.
Pu, Jiao; Jia, Mengying; Shi, Wei; Hu, Lulu; Wang, Fang; Niu, Yaqi; Tong, Qiaoying; Gong, Zhongcheng.
Afiliação
  • Pu J; Oncological Department of Oral & Maxillofacial Surgery, the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, China.
  • Jia M; Oncological Department of Oral & Maxillofacial Surgery, the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, China.
  • Shi W; Oncological Department of Oral & Maxillofacial Surgery, the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, China.
  • Hu L; Oncological Department of Oral & Maxillofacial Surgery, the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, China.
  • Wang F; Oncological Department of Oral & Maxillofacial Surgery, the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, China.
  • Niu Y; Oncological Department of Oral & Maxillofacial Surgery, the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, China.
  • Tong Q; Oncological Department of Oral & Maxillofacial Surgery, the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, China.
  • Gong Z; Oncological Department of Oral & Maxillofacial Surgery, the First Affiliated Hospital (the Affiliated Stomatological Hospital) of Xinjiang Medical University, Xinjiang Uygur Autonomous Region Institute of Stomatology, Urumqi, China.
J Oral Pathol Med ; 51(4): 388-394, 2022 Apr.
Article em En | MEDLINE | ID: mdl-35218237
BACKGROUND: NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3)-induced pyroptosis is involved in the development of a variety of autoimmune diseases, but its role in IgG4-related sialadenitis (IgG4-RS) is unclear. METHODS: Salivary gland tissues from 19 patients with IgG4-RS were designated the experimental group, and peritumoral tissues from 20 patients with benign salivary gland tumours were designated the control group. The cell morphology and fibrosis in the IgG4-RS samples were observed by haematoxylin-eosin (H&E) and Masson trichrome (MT) staining. Immunohistochemical (IHC) staining was used to determine pyroptosis-related proteins (NLRP3, ASC (apoptosis-associated speck-like protein containing a CARD), Caspase-1, GSDMD (gasdermin family members, including digestive dermatin D), interleukin 1ß (IL-1ß), and interleukin 18 (IL-18)) expression levels. RESULTS: Increased lymphoid follicle proliferation, germinal centre plasma cell infiltration, and irregular fibrosis were observed in the experimental group compared with the control group. The NLRP3, ASC, Caspase-1, GSDMD, IL-1ß, and IL-18 levels were significantly higher in the experimental group than in the control group (p < 0.0001). CONCLUSION: This study suggested that pyroptosis-related proteins might be involved in IgG4-RS pathogenesis. However, the specific cellular pathway involved and whether multiple cell death pathways contribute to the occurrence of IgG4-RS still need to be further studied.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sialadenite / Interleucina-18 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sialadenite / Interleucina-18 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article