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Understanding HAIs: Ally proteins in the fight against cancer.
Nonboe, Annika W; Bald, Zuzanna H; Vogel, Lotte K.
Afiliação
  • Nonboe AW; Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Bald ZH; Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
  • Vogel LK; Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
FEBS J ; 289(12): 3416-3418, 2022 06.
Article em En | MEDLINE | ID: mdl-35220685
ABSTRACT
Understanding how HAI-1 and HAI-2 regulate the epithelial serine protease matriptase may hold the key to curing epithelial-derived cancer. HAIs are serine protease inhibitors that inhibit matriptase and have a poorly understood effect on the presence of matriptase protein in cells. In this issue of The FEBS Journal, Yamashita et al. provide much-needed new insights into this effect, describing it as a 'chaperone-like function' of HAI-1. However, several observations suggest that matriptase folds correctly without HAIs and that HAIs are not chaperones. We introduce the concept of 'ally proteins' to categorize the poorly understood function of HAIs, distinguishing them from chaperones. Comment on https//doi.org/10.1111/febs.16348.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Proteínas Secretadas Inibidoras de Proteinases / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Proteínas Secretadas Inibidoras de Proteinases / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article