Immune response to influenza and pneumococcal vaccines in adults with inflammatory bowel disease: A systematic review and meta-analysis of 1429 patients.
Vaccine
; 40(13): 2076-2086, 2022 03 18.
Article
em En
| MEDLINE
| ID: mdl-35227523
ABSTRACT
BACKGROUND:
Patients with inflammatory bowel disease (IBD) have a high risk for infection. Pneumonia related to influenza and pneumococcal infection is one of the most common infection-related complications in IBD.AIMS:
To evaluate the immunogenicity of pneumococcal and influenza vaccination in patients with IBD receiving different treatments.METHODS:
We searched four databases for studies evaluating seroprotection and seroconversion rates after influenza or pneumococcal vaccination in IBD on 20th October 2020. In the meta-analysis, odds ratios (OR) were calculated with 95% confidence intervals (CI).RESULTS:
We included twelve studies (1429 patients with IBD) in this meta-analysis. The seroconversion rate after pneumococcal vaccination and the seroprotection rate after influenza vaccination were not significantly lower in patients receiving conventional immunosuppressive treatment compared to the non-immunosuppressed patients. Meanwhile, the seroconversion rate following pneumococcal vaccine was significantly lower in patients with anti-TNF mono- or combination therapy (ORâ¯=â¯0.28, CI 0.15-0.53, and ORâ¯=â¯0.27, CI 0.15-0.49, respectively). In the analysis of patients with IBD on conventional immunosuppressive monotherapy versus anti-TNF therapy, the seroprotection rate after influenza immunization did not differ between patients receiving either anti-TNF mono-or combination therapy (ORâ¯=â¯1.45, CI 0.62-3.38 and ORâ¯=â¯0.91, CI 0.37-2.22, respectively).CONCLUSION:
Our data suggest that the immunization against Pneumococcus and influenza is safe and immunogenic despite immunosuppression.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
/
Doenças Inflamatórias Intestinais
/
Influenza Humana
Tipo de estudo:
Systematic_reviews
Limite:
Adult
/
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article