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Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria.
Taft, Benjamin R; Yokokawa, Fumiaki; Kirrane, Tom; Mata, Anne-Catherine; Huang, Richard; Blaquiere, Nicole; Waldron, Grace; Zou, Bin; Simon, Oliver; Vankadara, Subramanyam; Chan, Wai Ling; Ding, Mei; Sim, Sandra; Straimer, Judith; Guiguemde, Armand; Lakshminarayana, Suresh B; Jain, Jay Prakash; Bodenreider, Christophe; Thompson, Christopher; Lanshoeft, Christian; Shu, Wei; Fang, Eric; Qumber, Jafri; Chan, Katherine; Pei, Luying; Chen, Yen-Liang; Schulz, Hanna; Lim, Jessie; Abas, Siti Nurdiana; Ang, Xiaoman; Liu, Yugang; Angulo-Barturen, Iñigo; Jiménez-Díaz, María Belén; Gamo, Francisco Javier; Crespo-Fernandez, Benigno; Rosenthal, Philip J; Cooper, Roland A; Tumwebaze, Patrick; Aguiar, Anna Caroline Campos; Campo, Brice; Campbell, Simon; Wagner, Jürgen; Diagana, Thierry T; Sarko, Christopher.
Afiliação
  • Taft BR; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 5959 Horton Street, Emeryville, California 94608, United States.
  • Yokokawa F; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 5959 Horton Street, Emeryville, California 94608, United States.
  • Kirrane T; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 5959 Horton Street, Emeryville, California 94608, United States.
  • Mata AC; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 5959 Horton Street, Emeryville, California 94608, United States.
  • Huang R; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 5959 Horton Street, Emeryville, California 94608, United States.
  • Blaquiere N; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 5959 Horton Street, Emeryville, California 94608, United States.
  • Waldron G; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 5959 Horton Street, Emeryville, California 94608, United States.
  • Zou B; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Simon O; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Vankadara S; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Chan WL; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Ding M; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Sim S; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Straimer J; Novartis Institute for Tropical Diseases, 5959 Horton Street, Emeryville, California 94608, United States.
  • Guiguemde A; Novartis Institute for Tropical Diseases, 5959 Horton Street, Emeryville, California 94608, United States.
  • Lakshminarayana SB; Novartis Institute for Tropical Diseases, 5959 Horton Street, Emeryville, California 94608, United States.
  • Jain JP; Novartis Institute for Tropical Diseases, 5959 Horton Street, Emeryville, California 94608, United States.
  • Bodenreider C; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Thompson C; Novartis Institutes for Biomedical Research, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.
  • Lanshoeft C; Novartis Institutes for Biomedical Research, Fabrikstrasse 14, Basel CH-4056, Switzerland.
  • Shu W; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 5959 Horton Street, Emeryville, California 94608, United States.
  • Fang E; Chemical Biology and Therapeutics, Novartis Institutes for Biomedical Research, 5959 Horton Street, Emeryville, California 94608, United States.
  • Qumber J; Novartis Institute for Tropical Diseases, 5959 Horton Street, Emeryville, California 94608, United States.
  • Chan K; Novartis Institute for Tropical Diseases, 5959 Horton Street, Emeryville, California 94608, United States.
  • Pei L; Novartis Institute for Tropical Diseases, 5959 Horton Street, Emeryville, California 94608, United States.
  • Chen YL; Novartis Institute for Tropical Diseases, 5959 Horton Street, Emeryville, California 94608, United States.
  • Schulz H; Novartis Institute for Tropical Diseases, 5959 Horton Street, Emeryville, California 94608, United States.
  • Lim J; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Abas SN; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Ang X; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Liu Y; Technical Research and Development, Global Drug Development, Novartis Pharmaceuticals Corporation, One Health Plaza, East Hanover, New Jersey 07936, United States.
  • Angulo-Barturen I; The Art of Discovery, Astondo Bidea, BIC Bizkaia building, no. 612 Derio 48160 Bizkaia, Basque Country, Spain.
  • Jiménez-Díaz MB; The Art of Discovery, Astondo Bidea, BIC Bizkaia building, no. 612 Derio 48160 Bizkaia, Basque Country, Spain.
  • Gamo FJ; Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain.
  • Crespo-Fernandez B; Tres Cantos Medicines Development Campus, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid 28760, Spain.
  • Rosenthal PJ; Department of Medicine, University of California, 533 Parnassus Avenue, San Francisco, California 94143, Unites States.
  • Cooper RA; Department of Natural Sciences and Mathematics, Dominican University of California, San Rafael, California 94901, United States.
  • Tumwebaze P; Infectious Diseases Research Collaboration, Plot 2C Nakasero Hill Road, P.O. Box 7475 Kampala, Uganda.
  • Aguiar ACC; São Carlos Institute of Physics, University of São Paulo, São Carlos, São Paulo 13563-120, Brazil.
  • Campo B; Medicines for Malaria Venture, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland.
  • Campbell S; Medicines for Malaria Venture, 20 Route de Pre-Bois, 1215 Geneva 15, Switzerland.
  • Wagner J; Novartis Institute for Tropical Diseases, 10 Biopolis Road, no. 05-01, Chromos, Singapore 138670, Singapore.
  • Diagana TT; Novartis Institute for Tropical Diseases, 5959 Horton Street, Emeryville, California 94608, United States.
  • Sarko C; Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 5959 Horton Street, Emeryville, California 94608, United States.
J Med Chem ; 65(5): 3798-3813, 2022 03 10.
Article em En | MEDLINE | ID: mdl-35229610
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Malária Falciparum / Antagonistas do Ácido Fólico / Malária / Antimaláricos Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Malária Falciparum / Antagonistas do Ácido Fólico / Malária / Antimaláricos Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article