Intranasal Niosomal In Situ Gel As A Novel Strategy for Improving Citicoline Efficacy and Brain Delivery in Treatment of Epilepsy: In Vitro and Ex Vivo Characterization and In Vivo Pharmacodynamics Investigation.

Bekhet, Marina A; Ali, Adel A; Kharshoum, Rasha M; El-Ela, Fatma I Abo; Salem, Heba F

Bekhet, Marina A; Ali, Adel A; Kharshoum, Rasha M; El-Ela, Fatma I Abo; Salem, Heba F.

Afiliação

Bekhet MA; Department of Pharmaceutics, Faculty of Pharmacy, Beni-Suef University, Egypt.
Ali AA; Department of Pharmaceutics, Faculty of Pharmacy, Beni-Suef University, Egypt. Electronic address: adel.ali@pharm.bsu.edu.eg.
Kharshoum RM; Department of Pharmaceutics, Faculty of Pharmacy, Beni-Suef University, Egypt.
El-Ela FIA; Department of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University, Egypt.
Salem HF; Department of Pharmaceutics, Faculty of Pharmacy, Beni-Suef University, Egypt.

J Pharm Sci ; 111(8): 2258-2269, 2022 08.

Article em En | MEDLINE | ID: mdl-35235845

Assuntos

Epilepsia; Nanopartículas Metálicas; Administração Intranasal; Animais; Encéfalo/metabolismo; Colesterol/metabolismo; Citidina Difosfato Colina/metabolismo; Portadores de Fármacos/metabolismo; Sistemas de Liberação de Medicamentos/métodos; Epilepsia/tratamento farmacológico; Ouro; Lipossomos/metabolismo; Tamanho da Partícula; Ratos

Palavras-chave

Brain computed tomography; Citicoline; Epilepsy; Niosomes; Pharmacodynamics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Epilepsia / Nanopartículas Metálicas Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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