Amino acid sensor conserved from bacteria to humans.
Proc Natl Acad Sci U S A
; 119(10): e2110415119, 2022 03 08.
Article
em En
| MEDLINE
| ID: mdl-35238638
ABSTRACT
SignificanceAmino acids are the building blocks of life and important signaling molecules. Despite their common structure, no universal mechanism for amino acid recognition by cellular receptors is currently known. We discovered a simple motif, which binds amino acids in various receptor proteins from all major life-forms. In humans, this motif is found in subunits of calcium channels that are implicated in pain and neurodevelopmental disorders. Our findings suggest that γ-aminobutyric acid-derived drugs bind to the same motif in human proteins that binds natural ligands in bacterial receptors, thus enabling future improvement of important drugs.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bactérias
/
Proteínas de Bactérias
/
Archaea
/
Proteínas Arqueais
/
Proteínas de Membrana
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article