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Epithelial-mesenchymal transition related to bone invasion in oral squamous cell carcinoma.
Vanini, Jaqueline Vaz; Koyama, Leonardo Kenji Sakaue; de Matos, Leandro Luongo; Junior, José Martins Figueredo; Cernea, Claudio Roberto; Nagano, Cibele Pidorodeski; Coutinho-Camillo, Cláudia Malheiros; Hsieh, Ricardo; Lourenço, Silvia Vanessa.
Afiliação
  • Vanini JV; Department of Stomatology, Dental School, University of São Paulo, São Paulo, Brazil.
  • Koyama LKS; Head and Neck Surgery Discipline, Medical School, University of São Paulo, São Paulo, Brazil.
  • de Matos LL; Head and Neck Surgery Discipline, Medical School, University of São Paulo, São Paulo, Brazil.
  • Junior JMF; Instituto do Câncer do Estado de São Paulo, ICESP/HCFMUSP (São Paulo Cancer Institute), São Paulo, Brazil.
  • Cernea CR; Department of Stomatology, Dental School, University of São Paulo, São Paulo, Brazil.
  • Nagano CP; Head and Neck Surgery Discipline, Medical School, University of São Paulo, São Paulo, Brazil.
  • Coutinho-Camillo CM; Instituto do Câncer do Estado de São Paulo, ICESP/HCFMUSP (São Paulo Cancer Institute), São Paulo, Brazil.
  • Hsieh R; Department of Stomatology, Dental School, University of São Paulo, São Paulo, Brazil.
  • Lourenço SV; AC Camargo Cancer Center, São Paulo, Brazil.
J Bone Oncol ; 33: 100418, 2022 Apr.
Article em En | MEDLINE | ID: mdl-35242512
INTRODUCTION: Bone invasion is an important prognostic factor in oral squamous cell carcinoma, leading to a lower survival rate and the use of aggressive treatment approaches. Epithelial-mesenchymal transition (EMT) is possibly involved in this process, because it is often related to mechanisms of cell motility and invasiveness. This study examined whether a panel of epithelial-mesenchymal markers are present in cases of oral squamous cell carcinoma with bone invasion and whether these proteins have any relationship with patients' clinical-pathological parameters and prognostic factors. METHODS: Immunohistochemical analysis of E-cadherin, twist, vimentin, TGFß1, and periostin was performed in paraffin-embedded samples of 62 oral squamous cell carcinoma cases. RESULTS: The analysis revealed that most cases (66%) presented with a dominant tumor infiltrative pattern in bone tissue, associated with lower survival rates, when compared with cases with a dominant erosive invasion pattern (P = 0.048). Twenty-seven cases (43%) expressed markers that were compatible with total or partial EMT at the tumor-bone interface. There was no association between evidence of total or partial EMT and other demographic or prognostic features. E-cadherin-positive cases were associated with tobacco smoking (P = 0.022); vimentin-positive cases correlated with tumors under 4 cm (P = 0.043). Twistexpression was observed in tumors with a dominant infiltrative pattern (P = 0.041) and was associated with the absence of periostin (P = 0.031). CONCLUSION: We observed evidence of total or partial EMT in oral squamous cell carcinoma bone invasion. The transcription factor twist appears to be involved in bone invasion and disease progression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article