NoteIdentification of 5,7-diacetamido-3,5,7,9-tetradeoxy-d-glycero-l-manno-non-2-ulosonic acid (di-N-acetyl-8-epipseudaminic acid) in the capsular polysaccharide of Acinetobacter baumannii Res546.
Carbohydr Res
; 513: 108531, 2022 Mar.
Article
em En
| MEDLINE
| ID: mdl-35245711
ABSTRACT
A structurally diverse capsular polysaccharide that surrounds the bacterial cell plays an important role in virulence of Acinetobacter baumannii, a cause of nosocomial infections worldwide. Various isomers of 5,7-diacylamido-3,5,7,9-tetradeoxynon-2-ulosonic acid have been identified as components of bacterial polysaccharides. In this work, we report on the identification of a new isomer having the d-glycero-l-manno configuration (8-epipseudaminic acid) in the capsular polysaccharide of A. baumannii Res546. The higher sugar was isolated by Smith degradation of the polysaccharide followed by mild acid hydrolysis and identified by a comparison with all isomers using NMR spectroscopy and optical rotation.
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01-internacional
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MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
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Cápsulas Bacterianas
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Acinetobacter baumannii
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article