Response prediction in patients with gastric and esophagogastric adenocarcinoma under neoadjuvant chemotherapy using targeted gene expression analysis and next-generation sequencing in pre-therapeutic biopsies.

Kleo, Karsten; Jovanovic, Vladimir M; Arndold, Alexander; Lehmann, Annika; Lammert, Hedwig; Berg, Erika; Harloff, Hannah; Treese, Christoph; Hummel, Michael; Daum, Severin

Kleo, Karsten; Jovanovic, Vladimir M; Arndold, Alexander; Lehmann, Annika; Lammert, Hedwig; Berg, Erika; Harloff, Hannah; Treese, Christoph; Hummel, Michael; Daum, Severin.

Afiliação

Kleo K; Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Jovanovic VM; Institute of Informatics, Bioinformatics Solution Center, Freie Universität (FU), Takustr. 9, 14195, Berlin, Germany.
Arndold A; Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Lehmann A; Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Lammert H; Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Berg E; Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Chariteplatz 1, 10117, Berlin, Germany.
Harloff H; Medical Department, Division of Gastroenterology, Infectious Diseases and Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany.
Treese C; Medical Department, Division of Gastroenterology, Infectious Diseases and Rheumatology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200, Berlin, Germany.
Hummel M; Experimental and Clinical Research Center, Charité University Medicine, Berlin and Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Chariteplatz 1, 10117, Berlin, Germany.
Daum S; Core Facility Genomics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Charitéplatz 1, 10117, Berlin, Germany.

J Cancer Res Clin Oncol ; 149(3): 1049-1061, 2023 Mar.

Article em En | MEDLINE | ID: mdl-35246724

Assuntos

Adenocarcinoma; Infecções por Vírus Epstein-Barr; Neoplasias Esofágicas; Neoplasias Gástricas; Humanos; Terapia Neoadjuvante; Neoplasias Gástricas/patologia; Infecções por Vírus Epstein-Barr/patologia; Variações do Número de Cópias de DNA; Herpesvirus Humano 4/genética; Junção Esofagogástrica/patologia; Instabilidade de Microssatélites; Perfilação da Expressão Gênica; Adenocarcinoma/patologia; Biópsia; Sequenciamento de Nucleotídeos em Larga Escala; Neoplasias Esofágicas/patologia

Palavras-chave

Gastric and esophagogastric adenocarcinoma; Histopathological response according to Becker score; Perioperative chemotherapy; Predictive biomarker in pre-therapeutic biopsies; Single nucleotide variants (SNV); copy number variations (CNV); gene expression

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Neoplasias Esofágicas / Adenocarcinoma / Infecções por Vírus Epstein-Barr Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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