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Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials.
McGarvey, Lorcan P; Birring, Surinder S; Morice, Alyn H; Dicpinigaitis, Peter V; Pavord, Ian D; Schelfhout, Jonathan; Nguyen, Allison Martin; Li, Qing; Tzontcheva, Anjela; Iskold, Beata; Green, Stuart A; Rosa, Carmen La; Muccino, David R; Smith, Jaclyn A.
Afiliação
  • McGarvey LP; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.
  • Birring SS; Centre for Human & Applied Physiological Sciences, School of Basic & Medical Biosciences, Faculty of Life Sciences & Medicine, King's College London, London, UK.
  • Morice AH; Respiratory Medicine, Hull York Medical School, Cottingham, UK.
  • Dicpinigaitis PV; Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY, USA.
  • Pavord ID; Oxford National Institute for Health Research Respiratory Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • Schelfhout J; Clinical Research, Merck & Co, Kenilworth, NJ, USA.
  • Nguyen AM; Clinical Research, Merck & Co, Kenilworth, NJ, USA.
  • Li Q; Clinical Research, Merck & Co, Kenilworth, NJ, USA.
  • Tzontcheva A; Clinical Research, Merck & Co, Kenilworth, NJ, USA.
  • Iskold B; Clinical Research, Merck & Co, Kenilworth, NJ, USA.
  • Green SA; Clinical Research, Merck & Co, Kenilworth, NJ, USA.
  • Rosa C; Clinical Research, Merck & Co, Kenilworth, NJ, USA.
  • Muccino DR; Clinical Research, Merck & Co, Kenilworth, NJ, USA.
  • Smith JA; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK. Electronic address: jacky.smith@manchester.ac.uk.
Lancet ; 399(10328): 909-923, 2022 03 05.
Article em En | MEDLINE | ID: mdl-35248186
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Sulfonamidas / Tosse Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Sulfonamidas / Tosse Tipo de estudo: Clinical_trials Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article