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The clinicopathological features and survival of Castleman disease: a multicenter Turkish study.
Yildiz, J; Bagci, M; Sayin, S; Kaya, A; Yilmaz, F; Ekinci, O; Dal, M S; Basturk, A; Aydogdu, I; Albayrak, M; Dogan, A; Erkurt, M A; Korkmaz, S; Ulas, T; Eser, B; Altuntas, F.
Afiliação
  • Yildiz J; Department of Hematology, Yenimahalle Training and Research Hospital, Yildirim Beyazit University, Ankara, Turkey. dr.jalevardi@hotmail.com.
Eur Rev Med Pharmacol Sci ; 26(4): 1131-1137, 2022 Feb.
Article em En | MEDLINE | ID: mdl-35253168
OBJECTIVE: In this study, we aimed to investigate the clinicopathological features and survival of CD, which is quite rare and has many unknowns. PATIENTS AND METHODS: This study was conducted by retrospectively evaluating patients diagnosed with CD in six different centers in Turkey. RESULTS: The median age of 33 patients included in the study was 49 and 51.5% (n = 17) of these patients were women. 18 (54.5%) patients were in the hyaline vascular subtype and most of the patients were UCD (n = 20, 60.6%). The most common involvement region was head and neck (n = 19, 57.5%). The UCD group was younger than the MCD group (p=0.027). Visceral lymph node involvement was higher in MCD than in UCD (p=0.001). Similarly, it was observed that there was more hepatomegaly (p=0.035) and splenomegaly (p=0.013) in the MCD group. During the median 19.5 months follow-up period, there were no patients who died. CONCLUSIONS: It was observed that UCD and MCD are different clinical entities. Promising survival times can be achieved with surgical and systemic treatments in both subtypes of this extremely rare disease. However, this result should be supported by well-designed prospective comprehensive studies.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperplasia do Linfonodo Gigante Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: Asia Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Hiperplasia do Linfonodo Gigante Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male País/Região como assunto: Asia Idioma: En Ano de publicação: 2022 Tipo de documento: Article