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A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling.
Chen, Jiandong; Byun, Hyuntae; Liu, Rui; Jung, I-Ji; Pu, Qinqin; Zhu, Clara Y; Tanchoco, Ethan; Alavi, Salma; Degnan, Patrick H; Ma, Amy T; Roggiani, Manuela; Beld, Joris; Goulian, Mark; Hsiao, Ansel; Zhu, Jun.
Afiliação
  • Chen J; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
  • Byun H; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
  • Liu R; Department of Microbiology & Plant Pathology, University of California, Riverside, CA 92521.
  • Jung IJ; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
  • Pu Q; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
  • Zhu CY; Harriton High School, Bryn Mawr, PA 19010.
  • Tanchoco E; Department of Microbiology & Plant Pathology, University of California, Riverside, CA 92521.
  • Alavi S; Department of Microbiology & Plant Pathology, University of California, Riverside, CA 92521.
  • Degnan PH; Department of Microbiology & Plant Pathology, University of California, Riverside, CA 92521.
  • Ma AT; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102.
  • Roggiani M; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104.
  • Beld J; Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19102.
  • Goulian M; Department of Biology, University of Pennsylvania, Philadelphia, PA 19104.
  • Hsiao A; Department of Microbiology & Plant Pathology, University of California, Riverside, CA 92521.
  • Zhu J; Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104.
Proc Natl Acad Sci U S A ; 119(11): e2121180119, 2022 03 15.
Article em En | MEDLINE | ID: mdl-35254905
ABSTRACT
SignificanceIn a polymicrobial battlefield where different species compete for nutrients and colonization niches, antimicrobial compounds are the sword and shield of commensal microbes in competition with invading pathogens and each other. The identification of an Escherichia coli-produced genotoxin, colibactin, and its specific targeted killing of enteric pathogens and commensals, including Vibrio cholerae and Bacteroides fragilis, sheds light on our understanding of intermicrobial interactions in the mammalian gut. Our findings elucidate the mechanisms through which genotoxins shape microbial communities and provide a platform for probing the larger role of enteric multibacterial interactions regarding infection and disease outcomes.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vibrio cholerae / Cólera / Interações Hospedeiro-Patógeno / Interações Microbianas / Microbioma Gastrointestinal / Mutagênicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vibrio cholerae / Cólera / Interações Hospedeiro-Patógeno / Interações Microbianas / Microbioma Gastrointestinal / Mutagênicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article