A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling.
Proc Natl Acad Sci U S A
; 119(11): e2121180119, 2022 03 15.
Article
em En
| MEDLINE
| ID: mdl-35254905
ABSTRACT
SignificanceIn a polymicrobial battlefield where different species compete for nutrients and colonization niches, antimicrobial compounds are the sword and shield of commensal microbes in competition with invading pathogens and each other. The identification of an Escherichia coli-produced genotoxin, colibactin, and its specific targeted killing of enteric pathogens and commensals, including Vibrio cholerae and Bacteroides fragilis, sheds light on our understanding of intermicrobial interactions in the mammalian gut. Our findings elucidate the mechanisms through which genotoxins shape microbial communities and provide a platform for probing the larger role of enteric multibacterial interactions regarding infection and disease outcomes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vibrio cholerae
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Cólera
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Interações Hospedeiro-Patógeno
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Interações Microbianas
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Microbioma Gastrointestinal
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Mutagênicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article