Inhibiting collagen I production and tumor cell colonization in the lung via miR-29a-3p loading of exosome-/liposome-based nanovesicles.
Acta Pharm Sin B
; 12(2): 939-951, 2022 Feb.
Article
em En
| MEDLINE
| ID: mdl-35256956
CPT-Exo, cisplatin elicited lung tumor exosomes; CTCs, circulating tumor cells; Collagen I; DOTAP, 1,2-dioleoyl-3-trimethylammonium propane; ECM, extra cellular matrix; EVs, extracellular vesicles; Exosomes; Fibroblasts; LLC, Lewis lung carcinoma; LLC-Exo, LLC-derived exosomes; Liposomal nanovesicle; Luc-LPX, Luc-lipoplex; Lung metastasis; NC inhibitor, negative control inhibitor; NC mimic, negative control mimic; PMN, pre-metastatic niche; Pre-metastatic niche; RNA-LPX, RNA-lipoplex; cDNA, complementary DNA; miR-29a-3p; miR-29a-3p-LPX, miR-29a-3p-lipoplex
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01-internacional
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MEDLINE
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En
Ano de publicação:
2022
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Article