Neural Signaling in Cancer.
Annu Rev Neurosci
; 45: 199-221, 2022 07 08.
Article
em En
| MEDLINE
| ID: mdl-35259916
ABSTRACT
Nervous system activity regulates development, homeostasis, and plasticity of the brain as well as other organs in the body. These mechanisms are subverted in cancer to propel malignant growth. In turn, cancers modulate neural structure and function to augment growth-promoting neural signaling in the tumor microenvironment. Approaching cancer biology from a neuroscience perspective will elucidate new therapeutic strategies for presently lethal forms of cancer. In this review, we highlight the neural signaling mechanisms recapitulated in primary brain tumors, brain metastases, and solid tumors throughout the body that regulate cancer progression.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article