Cyclin-Dependent Kinases (CDKs) and the Human Cytomegalovirus-Encoded CDK Ortholog pUL97 Represent Highly Attractive Targets for Synergistic Drug Combinations.

Wild, Markus; Hahn, Friedrich; Brückner, Nadine; Schütz, Martin; Wangen, Christina; Wagner, Sabrina; Sommerer, Mona; Strobl, Stefan; Marschall, Manfred

Wild, Markus; Hahn, Friedrich; Brückner, Nadine; Schütz, Martin; Wangen, Christina; Wagner, Sabrina; Sommerer, Mona; Strobl, Stefan; Marschall, Manfred.

Afiliação

Wild M; Institute for Clinical and Molecular Virology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054 Erlangen, Germany.
Hahn F; Institute for Clinical and Molecular Virology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054 Erlangen, Germany.
Brückner N; Institute for Clinical and Molecular Virology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054 Erlangen, Germany.
Schütz M; Institute for Clinical and Molecular Virology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054 Erlangen, Germany.
Wangen C; Institute for Clinical and Molecular Virology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054 Erlangen, Germany.
Wagner S; Institute for Clinical and Molecular Virology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054 Erlangen, Germany.
Sommerer M; Institute for Clinical and Molecular Virology, Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Schlossgarten 4, 91054 Erlangen, Germany.
Strobl S; 4SC AG/4SC Discovery GmbH, Fraunhoferstraße 22, 82152 Planegg-Martinsried, Germany.
Marschall M; BioNTech SE, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany.

Int J Mol Sci ; 23(5)2022 Feb 24.

Article em En | MEDLINE | ID: mdl-35269635

Assuntos

Quinases Ciclina-Dependentes; Citomegalovirus; Quinases Ciclina-Dependentes/metabolismo; Citomegalovirus/genética; Combinação de Medicamentos; Farmacorresistência Viral; Humanos; Proteínas Virais/metabolismo; Replicação Viral

Palavras-chave

antiviral drug; antiviral drug synergism; cyclin-dependent kinase (CDK); direct-acting antiviral (DAA); drug combinations; host-directed antiviral (HDA); human cytomegalovirus; new synergistic drug-target combinations; pharmaceutical kinase inhibitor (PKI); viral CDK pUL97 (vCDK)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Quinases Ciclina-Dependentes / Citomegalovirus Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google