The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-&#954;B pathway.

Farina, Floriana Maria; Serio, Simone; Hall, Ignacio Fernando; Zani, Stefania; Cassanmagnago, Giada Andrea; Climent, Montserrat; Civilini, Efrem; Condorelli, Gianluigi; Quintavalle, Manuela; Elia, Leonardo

The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell-monocyte crosstalk and protects against atherosclerosis via the NF-κB pathway.

Farina, Floriana Maria; Serio, Simone; Hall, Ignacio Fernando; Zani, Stefania; Cassanmagnago, Giada Andrea; Climent, Montserrat; Civilini, Efrem; Condorelli, Gianluigi; Quintavalle, Manuela; Elia, Leonardo.

Afiliação

Farina FM; IRCCS Humanitas Research Hospital, Via Manzoni 113, 20089 Rozzano (MI), Italy.
Serio S; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximillians-Universität (LMU) München, D-80336 Munich, Germany.
Hall IF; German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, D-80336 Munich, Germany.
Zani S; IRCCS Humanitas Research Hospital, Via Manzoni 113, 20089 Rozzano (MI), Italy.
Cassanmagnago GA; Humanitas University, Pieve Emanuele (MI), Italy.
Climent M; IRCCS Humanitas Research Hospital, Via Manzoni 113, 20089 Rozzano (MI), Italy.
Civilini E; IRCCS Humanitas Research Hospital, Via Manzoni 113, 20089 Rozzano (MI), Italy.
Condorelli G; Humanitas University, Pieve Emanuele (MI), Italy.
Quintavalle M; IRCCS Humanitas Research Hospital, Via Manzoni 113, 20089 Rozzano (MI), Italy.
Elia L; Humanitas University, Pieve Emanuele (MI), Italy.

Eur Heart J ; 43(43): 4562-4576, 2022 11 14.

Article em En | MEDLINE | ID: mdl-35292818

Assuntos

Aterosclerose; Músculo Liso Vascular; Humanos; Camundongos; Animais; Músculo Liso Vascular/metabolismo; NF-kappa B/genética; NF-kappa B/metabolismo; Histona-Lisina N-Metiltransferase/genética; Histona-Lisina N-Metiltransferase/metabolismo; Monócitos/metabolismo; Miócitos de Músculo Liso/metabolismo; Miócitos de Músculo Liso/patologia; Aterosclerose/genética; Aterosclerose/prevenção & controle; Aterosclerose/metabolismo; Camundongos Knockout; Inativação Gênica; Células Cultivadas

Palavras-chave

Dot1l; Atherosclerosis; Epigenetics; H3K79me2; Inflammation; Vascular smooth muscle cells

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aterosclerose / Músculo Liso Vascular Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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