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A single-cell atlas of human and mouse white adipose tissue.
Emont, Margo P; Jacobs, Christopher; Essene, Adam L; Pant, Deepti; Tenen, Danielle; Colleluori, Georgia; Di Vincenzo, Angelica; Jørgensen, Anja M; Dashti, Hesam; Stefek, Adam; McGonagle, Elizabeth; Strobel, Sophie; Laber, Samantha; Agrawal, Saaket; Westcott, Gregory P; Kar, Amrita; Veregge, Molly L; Gulko, Anton; Srinivasan, Harini; Kramer, Zachary; De Filippis, Eleanna; Merkel, Erin; Ducie, Jennifer; Boyd, Christopher G; Gourash, William; Courcoulas, Anita; Lin, Samuel J; Lee, Bernard T; Morris, Donald; Tobias, Adam; Khera, Amit V; Claussnitzer, Melina; Pers, Tune H; Giordano, Antonio; Ashenberg, Orr; Regev, Aviv; Tsai, Linus T; Rosen, Evan D.
Afiliação
  • Emont MP; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Jacobs C; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Essene AL; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Pant D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Tenen D; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Colleluori G; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Di Vincenzo A; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Jørgensen AM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Dashti H; Department of Experimental and Clinical Medicine, Center of Obesity, Marche Polytechnic University, Ancona, Italy.
  • Stefek A; Department of Experimental and Clinical Medicine, Center of Obesity, Marche Polytechnic University, Ancona, Italy.
  • McGonagle E; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark.
  • Strobel S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Laber S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Agrawal S; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Westcott GP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Kar A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Veregge ML; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Gulko A; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  • Srinivasan H; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Kramer Z; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • De Filippis E; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Merkel E; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Ducie J; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Boyd CG; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Gourash W; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Courcoulas A; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Lin SJ; Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic Scottsdale, AZ, USA.
  • Lee BT; Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Morris D; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Tobias A; Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Khera AV; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Claussnitzer M; Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Pers TH; Division of Plastic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Giordano A; Division of Plastic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Ashenberg O; Division of Plastic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Regev A; Division of Plastic Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Tsai LT; Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Rosen ED; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Nature ; 603(7903): 926-933, 2022 03.
Article em En | MEDLINE | ID: mdl-35296864
ABSTRACT
White adipose tissue, once regarded as morphologically and functionally bland, is now recognized to be dynamic, plastic and heterogenous, and is involved in a wide array of biological processes including energy homeostasis, glucose and lipid handling, blood pressure control and host defence1. High-fat feeding and other metabolic stressors cause marked changes in adipose morphology, physiology and cellular composition1, and alterations in adiposity are associated with insulin resistance, dyslipidemia and type 2 diabetes2. Here we provide detailed cellular atlases of human and mouse subcutaneous and visceral white fat at single-cell resolution across a range of body weight. We identify subpopulations of adipocytes, adipose stem and progenitor cells, vascular and immune cells and demonstrate commonalities and differences across species and dietary conditions. We link specific cell types to increased risk of metabolic disease and provide an initial blueprint for a comprehensive set of interactions between individual cell types in the adipose niche in leanness and obesity. These data comprise an extensive resource for the exploration of genes, traits and cell types in the function of white adipose tissue across species, depots and nutritional conditions.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atlas como Assunto / Resistência à Insulina / Diabetes Mellitus Tipo 2 / Tecido Adiposo Branco / Doenças Metabólicas Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Atlas como Assunto / Resistência à Insulina / Diabetes Mellitus Tipo 2 / Tecido Adiposo Branco / Doenças Metabólicas Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article