Compartment-specific tuning of dendritic feature selectivity by intracellular Ca2+ release.
Science
; 375(6586): eabm1670, 2022 03 18.
Article
em En
| MEDLINE
| ID: mdl-35298275
ABSTRACT
Dendritic calcium signaling is central to neural plasticity mechanisms that allow animals to adapt to the environment. Intracellular calcium release (ICR) from the endoplasmic reticulum has long been thought to shape these mechanisms. However, ICR has not been investigated in mammalian neurons in vivo. We combined electroporation of single CA1 pyramidal neurons, simultaneous imaging of dendritic and somatic activity during spatial navigation, optogenetic place field induction, and acute genetic augmentation of ICR cytosolic impact to reveal that ICR supports the establishment of dendritic feature selectivity and shapes integrative properties determining output-level receptive fields. This role for ICR was more prominent in apical than in basal dendrites. Thus, ICR cooperates with circuit-level architecture in vivo to promote the emergence of behaviorally relevant plasticity in a compartment-specific manner.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cálcio
/
Dendritos
/
Retículo Endoplasmático
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Região CA1 Hipocampal
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Células de Lugar
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article