Recombination resolves the cost of horizontal gene transfer in experimental populations of Helicobacter pylori.
Proc Natl Acad Sci U S A
; 119(12): e2119010119, 2022 03 22.
Article
em En
| MEDLINE
| ID: mdl-35298339
ABSTRACT
Horizontal gene transfer (HGT) is important for microbial evolution, yet we know little about the fitness effects and dynamics of horizontally transferred genetic variants. In this study, we evolve laboratory populations of Helicobacter pylori, which take up DNA from their environment by natural transformation, and measure the fitness effects of thousands of transferred genetic variants. We find that natural transformation increases the rate of adaptation but comes at the cost of significant genetic load. We show that this cost is circumvented by recombination, which increases the efficiency of selection by decoupling deleterious and beneficial genetic variants. Our results show that adaptation with HGT, pervasive in natural microbial populations, is shaped by a combination of selection, recombination, and genetic drift not accounted for in existing models of evolution.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Helicobacter pylori
/
Transferência Genética Horizontal
Tipo de estudo:
Health_economic_evaluation
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article