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The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway.
Carlile, Graeme W; Yang, Qi; Matthes, Elizabeth; Liao, Jie; Birault, Véronique; Sneddon, Helen F; Poole, Darren L; Hall, Callum J; Hanrahan, John W; Thomas, David Y.
Afiliação
  • Carlile GW; Department of Biochemistry, Cystic Fibrosis Translational Research Centre, McGill University, McIntyre Medical Sciences Building, 3655 Promenade Sir William Osler, Montreal, QC, H3G 1Y6, Canada. graeme.carlile@mcgill.ca.
  • Yang Q; Department of Human Genetics, Cystic Fibrosis Translational Research Centre, McGill University, Montreal, QC, H3G 1Y6, Canada. graeme.carlile@mcgill.ca.
  • Matthes E; Department of Biochemistry, Cystic Fibrosis Translational Research Centre, McGill University, McIntyre Medical Sciences Building, 3655 Promenade Sir William Osler, Montreal, QC, H3G 1Y6, Canada.
  • Liao J; Department of Human Genetics, Cystic Fibrosis Translational Research Centre, McGill University, Montreal, QC, H3G 1Y6, Canada.
  • Birault V; Department of Physiology, McGill Cystic Fibrosis Translational Research Centre, McGill University, Montreal, QC, H3G 1Y6, Canada.
  • Sneddon HF; Department of Physiology, McGill Cystic Fibrosis Translational Research Centre, McGill University, Montreal, QC, H3G 1Y6, Canada.
  • Poole DL; Translation Department, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
  • Hall CJ; Department of Chemistry, Green Chemistry Centre of Excellence, University of York, Heslington, York, YO10 5DD, UK.
  • Hanrahan JW; Medicinal Chemistry, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK.
  • Thomas DY; Medicinal Chemistry, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK.
Sci Rep ; 12(1): 4595, 2022 03 17.
Article em En | MEDLINE | ID: mdl-35302062
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glafenina / Fibrose Cística Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glafenina / Fibrose Cística Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article