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Fasting blood glucose in a Ghanaian adult is causally affected by malaria parasite load: a mechanistic case study using convergent cross mapping.
Abidha, Carol A; Amoako, Yaw Ampem; Nyamekye, Richard King; Bedu-Addo, George; Grziwotz, Florian; Mockenhaupt, Frank P; Telschow, Arndt; Danquah, Ina.
Afiliação
  • Abidha CA; Faculty of Medicine and University Hospital, Heidelberg Institute of Global Health (HIGH), Heidelberg University, Heidelberg, Germany. akinyiabidha@gmail.com.
  • Amoako YA; Komfo Anokye Teaching Hospital, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Nyamekye RK; Agogo Presbyterian Hospital, Agogo, Ghana.
  • Bedu-Addo G; Komfo Anokye Teaching Hospital, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Grziwotz F; Institute for Evolution and Biodiversity, Westfälische Wilhelms-Universität Münster, Münster, Germany.
  • Mockenhaupt FP; Institute of Tropical Medicine and International Health, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
  • Telschow A; Institute for Evolution and Biodiversity, Westfälische Wilhelms-Universität Münster, Münster, Germany.
  • Danquah I; Institute for Environmental Systems Research, Osnabrück University, Osnabrück, Germany.
Malar J ; 21(1): 93, 2022 Mar 18.
Article em En | MEDLINE | ID: mdl-35303892
BACKGROUND: Adults with diabetes mellitus (DM) in malaria-endemic areas might be more susceptible to Plasmodium infection than healthy individuals. Herein, the study was aimed at verifying the hypothesis that increased fasting blood glucose (FBG) promotes parasite growth as reflected by increased parasite density. METHODS: Seven adults without DM were recruited in rural Ghana to determine the relationships between FBG and malaria parasite load. Socio-economic data were recorded in questionnaire-based interviews. Over a period of 6 weeks, FBG and Plasmodium sp. Infection were measured in peripheral blood samples photometrically and by polymerase chain reaction (PCR)-assays, respectively. Daily physical activity and weather data were documented via smartphone recording. For the complex natural systems of homeostatic glucose control and Plasmodium sp. life cycle, empirical dynamic modelling was applied. RESULTS: At baseline, four men and three women (median age, 33 years; interquartile range, 30-48) showed a median FBG of 5.5 (5.1-6.0 mmol/L); one participant had an asymptomatic Plasmodium sp. infection (parasite density: 240/µL). In this participant, convergent cross mapping (CCM) for 34 consecutive days, showed that FBG was causally affected by parasite density (p < 0.02), while the reciprocal relationship was not discernible (p > 0.05). Additionally, daily ambient temperature affected parasite density (p < 0.01). CONCLUSION: In this study population living in a malaria-endemic area, time series analyses were successfully piloted for the relationships between FBG and Plasmodium sp. density. Longer observation periods and larger samples are required to confirm these findings and determine the direction of causality.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Malária Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Africa Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Malária Tipo de estudo: Prognostic_studies Limite: Adult / Female / Humans / Male País/Região como assunto: Africa Idioma: En Ano de publicação: 2022 Tipo de documento: Article