GRASP depletion-mediated Golgi fragmentation impairs glycosaminoglycan synthesis, sulfation, and secretion.

Ahat, Erpan; Song, Yuefan; Xia, Ke; Reid, Whitney; Li, Jie; Bui, Sarah; Zhang, Fuming; Linhardt, Robert J; Wang, Yanzhuang

Ahat, Erpan; Song, Yuefan; Xia, Ke; Reid, Whitney; Li, Jie; Bui, Sarah; Zhang, Fuming; Linhardt, Robert J; Wang, Yanzhuang.

Afiliação

Ahat E; Department of Molecular, Cellular and Developmental Biology, University of Michigan, 1105 North University Avenue, Ann Arbor, MI, 48109-1085, USA.
Song Y; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Xia K; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Reid W; Department of Molecular, Cellular and Developmental Biology, University of Michigan, 1105 North University Avenue, Ann Arbor, MI, 48109-1085, USA.
Li J; Department of Molecular, Cellular and Developmental Biology, University of Michigan, 1105 North University Avenue, Ann Arbor, MI, 48109-1085, USA.
Bui S; Department of Molecular, Cellular and Developmental Biology, University of Michigan, 1105 North University Avenue, Ann Arbor, MI, 48109-1085, USA.
Zhang F; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA.
Linhardt RJ; Department of Chemistry and Chemical Biology, Center for Biotechnology and Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA. linhar@rpi.edu.
Wang Y; Department of Molecular, Cellular and Developmental Biology, University of Michigan, 1105 North University Avenue, Ann Arbor, MI, 48109-1085, USA. yzwang@umich.edu.

Cell Mol Life Sci ; 79(4): 199, 2022 Mar 21.

Article em En | MEDLINE | ID: mdl-35312866

Assuntos

Glicosaminoglicanos/metabolismo; Complexo de Golgi/metabolismo; Proteínas da Matriz do Complexo de Golgi/fisiologia; Metabolismo dos Carboidratos/genética; Sequência de Carboidratos/genética; Sulfatos de Condroitina/química; Sulfatos de Condroitina/metabolismo; Deleção de Genes; Técnicas de Silenciamento de Genes; Complexo de Golgi/patologia; Proteínas da Matriz do Complexo de Golgi/genética; Células HeLa; Heparitina Sulfato/química; Heparitina Sulfato/metabolismo; Humanos; Via Secretória/genética; Sulfatos/metabolismo

Palavras-chave

Chondroitin sulfate (CS); GRASP55; GRASP65; Golgi; Heparan sulfate (HS); Proteomic; RNAseq; Sulfation; Synthesis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas da Matriz do Complexo de Golgi / Glicosaminoglicanos / Complexo de Golgi Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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