Poly-guanidine shows high cytotoxicity in glioma cell cultures and glioma stem cells.

Márquez, Marcela; Olausson, Karl Holmberg; Alaiya, Ayodele; Nilsson, Sten; Meurling, Lennart; Holmberg, Anders R

Márquez, Marcela; Olausson, Karl Holmberg; Alaiya, Ayodele; Nilsson, Sten; Meurling, Lennart; Holmberg, Anders R.

Afiliação

Márquez M; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden. Marcela.Marquez-Holmberg@ki.se.
Olausson KH; Universidad Autónoma de Nuevo León, Centro de Investigación Y Desarrollo en Ciencias de La Salud, Monterrey, Nuevo Leon, Mexico. Marcela.Marquez-Holmberg@ki.se.
Alaiya A; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Nilsson S; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.
Meurling L; Proteomic Unit, Stem Cell and Tissue Re-Engineering Program, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Holmberg AR; Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

Invest New Drugs ; 40(3): 565-575, 2022 06.

Article em En | MEDLINE | ID: mdl-35312943

Assuntos

Neoplasias Encefálicas; Glioblastoma; Glioma; Neoplasias Encefálicas/patologia; Técnicas de Cultura de Células; Linhagem Celular Tumoral; Resistencia a Medicamentos Antineoplásicos; Glioblastoma/tratamento farmacológico; Glioma/metabolismo; Guanidina/farmacologia; Guanidina/uso terapêutico; Humanos; Células-Tronco Neoplásicas; Temozolomida/farmacologia; Temozolomida/uso terapêutico

Palavras-chave

Cell-killing efficacy; Glioma cells; New spheroid fluorometric cytotoxicity assay; Patient-derived glioma cell lines (PDGCLs); Poly-guanidine; Sialic acid

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma / Glioma Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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