Decyanation-(hetero)arylation of malononitriles to access α-(hetero)arylnitriles.
Org Biomol Chem
; 20(30): 5933-5937, 2022 08 03.
Article
em En
| MEDLINE
| ID: mdl-35315852
ABSTRACT
Quaternary α-(hetero)arylnitriles are desirable biologically relevant products, however the existing methods for their synthesis can be unselective or require the use of undesirable reagents, such as cyanide salts. Herein we report a one-pot method for transnitrilation-mediated decyanation-metalation of disubstituted malononitriles, followed by treatment with (hetero)aryl electrophiles to access quaternary α-(hetero)arylnitrile products. A number of products were prepared using this method (34 examples, 27-99% yield). This method highlights the usefulness of malononitriles as precursors for alkylnitrile-containing compounds.
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01-internacional
Base de dados:
MEDLINE
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Sais
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article