Decreased expression of protein <i>O</i>-linked mannose ß-1,2-<i>N</i>-acetylglucosaminyltransferase 1 contributes to Alzheimer's disease-like pathologies.

Feng, Yuxue; Jiang, Hanxiao; Li, Gongbo; He, Guiqiong; Li, Xiaofeng

Decreased expression of protein O-linked mannose ß-1,2-N-acetylglucosaminyltransferase 1 contributes to Alzheimer's disease-like pathologies.

Feng, Yuxue; Jiang, Hanxiao; Li, Gongbo; He, Guiqiong; Li, Xiaofeng.

Afiliação

Feng Y; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Jiang H; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Li G; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
He G; Institute of Neuroscience, Chongqing Medical University, Chongqing, People's Republic of China.
Li X; Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

J Neurophysiol ; 127(4): 1067-1074, 2022 04 01.

Article em En | MEDLINE | ID: mdl-35320023

Assuntos

Doença de Alzheimer; Manose; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/metabolismo; Animais; Modelos Animais de Doenças; Camundongos; Camundongos Transgênicos; N-Acetilglucosaminiltransferases/genética; Proteínas tau/genética; Proteínas tau/metabolismo

Palavras-chave

Alzheimer's disease; POMGnT1; mannosylation; posttranslational modifications

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Manose Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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