Preparation, Identification, Molecular Docking Study and Protective Function on HUVECs of Novel ACE Inhibitory Peptides from Protein Hydrolysate of Skipjack Tuna Muscle.

Zheng, Shuo-Lei; Luo, Qian-Bin; Suo, Shi-Kun; Zhao, Yu-Qin; Chi, Chang-Feng; Wang, Bin

Zheng, Shuo-Lei; Luo, Qian-Bin; Suo, Shi-Kun; Zhao, Yu-Qin; Chi, Chang-Feng; Wang, Bin.

Afiliação

Zheng SL; Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.
Luo QB; National and Provincial Joint Laboratory of Exploration and Utilization of Marine Aquatic Genetic Resources, National Engineering Research Center of Marine Facilities Aquaculture, School of Marine Science and Technology, Zhejiang Ocean University, Zhoushan 316022, China.
Suo SK; Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.
Zhao YQ; Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.
Chi CF; National and Provincial Joint Laboratory of Exploration and Utilization of Marine Aquatic Genetic Resources, National Engineering Research Center of Marine Facilities Aquaculture, School of Marine Science and Technology, Zhejiang Ocean University, Zhoushan 316022, China.
Wang B; Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, China.

Mar Drugs ; 20(3)2022 Feb 27.

Article em En | MEDLINE | ID: mdl-35323475

Assuntos

Inibidores da Enzima Conversora de Angiotensina; Músculo Esquelético/química; Peptídeos; Atum; Sequência de Aminoácidos; Inibidores da Enzima Conversora de Angiotensina/química; Inibidores da Enzima Conversora de Angiotensina/isolamento & purificação; Inibidores da Enzima Conversora de Angiotensina/farmacologia; Animais; Sobrevivência Celular/efeitos dos fármacos; Endotelina-1/metabolismo; Alimento Funcional; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Hidrólise; Simulação de Acoplamento Molecular; Óxido Nítrico/metabolismo; Peptídeos/química; Peptídeos/isolamento & purificação; Peptídeos/farmacologia; Hidrolisados de Proteína/química; Subtilisinas/química

Palavras-chave

angiotensin-I-converting enzyme (ACE) peptide; endothelin-1 (ET-1); molecular docking; nitric oxide (NO); skipjack tuna (Katsuwonus pelamis) muscle

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Atum / Inibidores da Enzima Conversora de Angiotensina / Músculo Esquelético Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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