Relationship between Oxidative Stress Markers and Presence of Chronic Total Occlusion in Coronary Artery Disease.
J Coll Physicians Surg Pak
; 32(4): 430-434, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35330512
ABSTRACT
OBJECTIVE:
To investigate the relationship between chronic total occlusion (CTO) development and oxidative stress markers in stable coronary artery patients. STUDYDESIGN:
A cohort study. PLACE AND DURATION OF STUDY Cardiology Clinic, Kahramanmaras Sutcu Imam University Medical Faculty, between January 2018 and December 2019.METHODOLOGY:
Patients, who underwent coronary angiography for stable chest pain, were consecutively included. The study group consisted of those with CTO and the control group from those without CTO. Serum total oxidant/anti-oxidant, dynamic thiol/disulfide, antioxidant (ascorbate, alfa-tocopherol, beta-carotene) vitamin levels, and routine biochemistry tests of the patients were compared.RESULTS:
The study group (24 men, 5 women, mean age 63.79 ± 9.21 years) and control group (23 men, 6 women, mean age 61.38 ± 8.20 years) consisted of 29 patients each. The oxidative stress markers (total thiol, native thiol, disulfide, reduced thiol ratio, oxidized thiol ratio, thiol oxidation-reduction ratio, total antioxidant status, total oxidant status, and vitamin E) were found to have similar values between the groups. However, of the anti-oxidative vitamins, vitamin C, vitamin A and vitamin C/vitamin E ratio were significantly lower in the CTO group and predicted a CTO lesion (AUC 0.084, p<0.001, 95% CI 0.007-0.162; AUC 0.285, p=0.005, 95% CI 0.154-0.416 and AUC 0.181, p <0.001, 95% CI 0.062-0.299, respectively).CONCLUSION:
The lower serum vitamin C and vitamin A levels and low vitamin C/vitamin E ratio may be useful in predicting the risk of CTO in stable patients with non-critical stenosis in coronary angiography. KEY WORDS Chronic total occlusion, Oxidative balance, Stable coronary artery disease, Vitamin A, Vitamin C, Vitamin C / vitamin A ratio.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
Tipo de estudo:
Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article