MetaLnc9-Antisense RNA Contributes to Lung Cancer Metastasis via Modulating RNA-RNA Duplex with MetaLnc9.
DNA Cell Biol
; 41(4): 390-399, 2022 Apr.
Article
em En
| MEDLINE
| ID: mdl-35333617
ABSTRACT
Lung cancer is a common life-threatening tumor with high malignancy and high invasiveness. Long non-coding RNAs (lncRNAs) are involved in almost every stage of tumor initiation and progression. Here, we identified an antisense lncRNA, MetaLnc9 antisense (Metalnc9-AS), which arises from the antisense strand of Metalnc9, located on chr9q34.11, while its biological function and mechanism are not clear in lung cancer. In this study, we demonstrated that the expression of Metalnc9-AS was upregulated in non-small cell lung cancer (NSCLC) tissues compared with corresponding non-tumorous tissues. The gain of MetaLnc9-AS was highly associated with the malignant features of NSCLC. Overexpression of MetaLnc9-AS enhanced tumor metastasis in vitro and in vivo. Mechanically, MetaLnc9-AS could form an RNA-RNA hybrid with its cognate sense counterpart, MetaLnc9, to regulate its expression in NSCLC cells, and that such complexes were protected from ribonuclease degradation. Thus, Metalnc9-AS might be a potential and effective treatment for NSCLC.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
RNA Antissenso
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Carcinoma Pulmonar de Células não Pequenas
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RNA Longo não Codificante
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Neoplasias Pulmonares
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article