Sesquiterpenoids from the rhizomes of Homalomena pendula and their anti-inflammatory activities.
Nat Prod Res
; 37(15): 2559-2567, 2023.
Article
em En
| MEDLINE
| ID: mdl-35337228
ABSTRACT
Sixteen sesquiterpenoids including two new ones, homalolides A - B (1â2), were firstly isolated from the methanolic extract of the rhizomes of Homalomena pendula collected in Vietnam. The structures and relative stereochemistry of new compounds were elucidated by 1D-/2D-NMR, IR, UV and HRESIMS analyses. The GCMS experiment demonstrated that homalolide A (1) is an artifact due to the methylation during methanolic extraction process. All isolates (1â16) were tested for their inhibitory activities against lipopolysaccharide-induced nitric oxide production in the RAW 264.7 macrophage cell line. Compounds 1, 3, 6â8, 10â12 displayed moderate inhibitory effect on NO production with IC50 values ranging from 35.41 to 64.06 µM.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Araceae
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article