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Tobacco smoking and binge alcohol use are associated with incident venous thromboembolism in an HIV cohort.
Luu, Brandon; Ruderman, Stephanie; Nance, Robin; Delaney, Joseph A C; Ma, Jimmy; Hahn, Andrew; Heckbert, Susan R; Budoff, Matthew J; Crothers, Kristina; Mathews, William C; Christopolous, Katerina; Hunt, Peter W; Eron, Joseph; Moore, Richard; Keruly, Jeanne; Lober, William B; Burkholder, Greer A; Willig, Amanda; Chander, Geetanjali; McCaul, Mary E; Cropsey, Karen; O'Cleirigh, Conall; Peter, Inga; Feinstein, Matthew; Tsui, Judith I; Lindstroem, Sara; Saag, Michael; Kitahata, Mari M; Crane, Heidi M; Drumright, Lydia N; Whitney, Bridget M.
Afiliação
  • Luu B; Northern Ontario School of Medicine, Thunder Bay, Ontario, Canada.
  • Ruderman S; University of Washington, Seattle, Washington, USA.
  • Nance R; University of Washington, Seattle, Washington, USA.
  • Delaney JAC; University of Washington, Seattle, Washington, USA.
  • Ma J; University of Manitoba, Winnipeg, Manitoba, Canada.
  • Hahn A; University of Washington, Seattle, Washington, USA.
  • Heckbert SR; University of Washington, Seattle, Washington, USA.
  • Budoff MJ; University of Washington, Seattle, Washington, USA.
  • Crothers K; Lundquist Institute at Harbor-UCLA, Torrance, California, USA.
  • Mathews WC; University of Washington, Seattle, Washington, USA.
  • Christopolous K; University of California, San Diego, California, USA.
  • Hunt PW; University of California, San Francisco, California, USA.
  • Eron J; University of California, San Francisco, California, USA.
  • Moore R; University of North Carolina, Chapel Hill, North Carolina, USA.
  • Keruly J; Johns Hopkins University, Baltimore, Maryland, USA.
  • Lober WB; Johns Hopkins University, Baltimore, Maryland, USA.
  • Burkholder GA; University of Washington, Seattle, Washington, USA.
  • Willig A; University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Chander G; University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • McCaul ME; Johns Hopkins University, Baltimore, Maryland, USA.
  • Cropsey K; Johns Hopkins University, Baltimore, Maryland, USA.
  • O'Cleirigh C; University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Peter I; Massachusetts General Hospital, Boston, Massachusetts, USA.
  • Feinstein M; Mount Sinai Hospital, New York, New York, USA.
  • Tsui JI; Northwestern University, Chicago, Illinois, USA.
  • Lindstroem S; University of Washington, Seattle, Washington, USA.
  • Saag M; University of Washington, Seattle, Washington, USA.
  • Kitahata MM; University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Crane HM; University of Washington, Seattle, Washington, USA.
  • Drumright LN; University of Washington, Seattle, Washington, USA.
  • Whitney BM; University of Washington, Seattle, Washington, USA.
HIV Med ; 23(10): 1051-1060, 2022 11.
Article em En | MEDLINE | ID: mdl-35343038
ABSTRACT

BACKGROUND:

People with HIV (PWH) are at increased risk of cardiovascular comorbidities and substance use is a potential predisposing factor. We evaluated associations of tobacco smoking and alcohol use with venous thromboembolism (VTE) in PWH.

METHODS:

We assessed incident, centrally adjudicated VTE among 12 957 PWH within the Centers for AIDS Research Network of Integrated Clinical Systems (CNICS) cohort between January 2009 and December 2018. Using separate Cox proportional hazards models, we evaluated associations of time-updated alcohol and cigarette use with VTE, adjusting for demographic and clinical characteristics. Smoking was evaluated as pack-years and never, former, or current use with current cigarettes per day. Alcohol use was parameterized using categorical and continuous alcohol use score, frequency of use, and binge frequency.

RESULTS:

During a median of 3.6 years of follow-up, 213 PWH developed a VTE. One-third of PWH reported binge drinking and 40% reported currently smoking. In adjusted analyses, risk of VTE was increased among both current (HR 1.44, 95% CI 1.02-2.03) and former (HR 1.44, 95% CI 0.99-2.07) smokers compared to PWH who never smoked. Additionally, total pack-years among ever-smokers (HR 1.10 per 5 pack-years; 95% CI 1.03-1.18) was associated with incident VTE in a dose-dependent manner. Frequency of binge drinking was associated with incident VTE (HR 1.30 per 7 days/month, 95% CI 1.11-1.52); however, alcohol use frequency was not. Severity of alcohol use was not significantly associated with VTE.

CONCLUSIONS:

Current smoking and pack-year smoking history were dose-dependently associated with incident VTE among PWH in CNICS. Binge drinking was also associated with VTE. Interventions for smoking and binge drinking may decrease VTE risk among PWH.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Tromboembolia Venosa / Consumo Excessivo de Bebidas Alcoólicas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por HIV / Tromboembolia Venosa / Consumo Excessivo de Bebidas Alcoólicas Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article