Salivary gland function, development, and regeneration.
Physiol Rev
; 102(3): 1495-1552, 2022 07 01.
Article
em En
| MEDLINE
| ID: mdl-35343828
ABSTRACT
Salivary glands produce and secrete saliva, which is essential for maintaining oral health and overall health. Understanding both the unique structure and physiological function of salivary glands, as well as how they are affected by disease and injury, will direct the development of therapy to repair and regenerate them. Significant recent advances, particularly in the OMICS field, increase our understanding of how salivary glands develop at the cellular, molecular, and genetic levels the signaling pathways involved, the dynamics of progenitor cell lineages in development, homeostasis, and regeneration, and the role of the extracellular matrix microenvironment. These provide a template for cell and gene therapies as well as bioengineering approaches to repair or regenerate salivary function.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Glândulas Salivares
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article