Serum exosomal miR-16-5p functions as a tumor inhibitor and a new biomarker for PD-L1 inhibitor-dependent immunotherapy in lung adenocarcinoma by regulating PD-L1 expression.

Chen, Hua-Lin; Luo, Yi-Ping; Lin, Mu-Wen; Peng, Xiao-Xia; Liu, Mei-Liang; Wang, Yong-Cun; Li, Shu-Jun; Yang, Dong-Hong; Yang, Zhi-Xiong

Chen, Hua-Lin; Luo, Yi-Ping; Lin, Mu-Wen; Peng, Xiao-Xia; Liu, Mei-Liang; Wang, Yong-Cun; Li, Shu-Jun; Yang, Dong-Hong; Yang, Zhi-Xiong.

Afiliação

Chen HL; Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Luo YP; Department of Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Lin MW; Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Peng XX; Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Liu ML; Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Wang YC; Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Li SJ; Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Yang DH; Department of Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Yang ZX; Department of Pulmonary Oncology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Cancer Med ; 11(13): 2627-2643, 2022 07.

Article em En | MEDLINE | ID: mdl-35347894

Assuntos

Adenocarcinoma de Pulmão; Exossomos; Imunoterapia; Neoplasias Pulmonares; MicroRNAs; Adenocarcinoma de Pulmão/genética; Adenocarcinoma de Pulmão/terapia; Animais; Antígeno B7-H1/genética; Antígeno B7-H1/metabolismo; Biomarcadores/metabolismo; Exossomos/metabolismo; Humanos; Inibidores de Checkpoint Imunológico/uso terapêutico; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/terapia; Camundongos; Camundongos Nus; MicroRNAs/sangue

Palavras-chave

LUAD; PD-L1; biomarker for inhibitor-dependent immunotherapy; serum exosomal miR-16-5p; tumor suppressor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / Exossomos / Adenocarcinoma de Pulmão / Imunoterapia / Neoplasias Pulmonares Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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