A bioinformatic approach of targeting SARS-CoV-2 replication by silencing a conserved alternative reserve of the orf8 gene using host miRNAs.

Goud, Vaggu Raghavendra; Chakraborty, Rajasree; Chakraborty, Averi; Lavudi, Kousalya; Patnaik, Sriram; Sharma, Swati; Patnaik, Srinivas

Goud, Vaggu Raghavendra; Chakraborty, Rajasree; Chakraborty, Averi; Lavudi, Kousalya; Patnaik, Sriram; Sharma, Swati; Patnaik, Srinivas.

Afiliação

Goud VR; School of Biotechnology, KIIT University, Bhubaneswar, India.
Chakraborty R; School of Biotechnology, KIIT University, Bhubaneswar, India.
Chakraborty A; School of Biotechnology, KIIT University, Bhubaneswar, India.
Lavudi K; School of Biotechnology, KIIT University, Bhubaneswar, India.
Patnaik S; School of Biotechnology, KIIT University, Bhubaneswar, India.
Sharma S; School of Biotechnology, KIIT University, Bhubaneswar, India; Dept. of Skill Buildings Shri Ramasamy Memorial University, Sikkim, Gangtok, 737102, India.
Patnaik S; School of Biotechnology, KIIT University, Bhubaneswar, India. Electronic address: srinivas.patnaik@kiitbiotech.ac.in.

Comput Biol Med ; 145: 105436, 2022 06.

Article em En | MEDLINE | ID: mdl-35366472

Assuntos

COVID-19; MicroRNAs; COVID-19/genética; Biologia Computacional; Humanos; MicroRNAs/genética; Pandemias; RNA Mensageiro; SARS-CoV-2/genética; Proteínas Virais/genética; Proteínas Virais/metabolismo

Palavras-chave

Gene silencing; Molecular docking; Omicron; SARS-CoV-2; miRNAs; orf7a; orf8

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: MicroRNAs / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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