Design, synthesis, cytotoxicity, and molecular docking studies of novel thiazolyl-hydrazone derivatives as histone lysine acetyl-transferase inhibitors and apoptosis inducers.

Abbas, Eman M H; Farghaly, Thoraya A; Sabour, Rehab; Shaaban, Mohamed R; Abdallah, Zeinab A

Abbas, Eman M H; Farghaly, Thoraya A; Sabour, Rehab; Shaaban, Mohamed R; Abdallah, Zeinab A.

Afiliação

Abbas EMH; Department of Chemistry, Natural and Microbial Products, National Research Center, Dokki, Cairo, Egypt.
Farghaly TA; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.
Sabour R; Department of Pharmaceutical Chemistry, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
Shaaban MR; Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah, Almukkarramah, Saudi Arabia.
Abdallah ZA; Department of Chemistry, Faculty of Science, Cairo University, Giza, Egypt.

Arch Pharm (Weinheim) ; 355(7): e2200076, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35393652

Assuntos

Antineoplásicos; Lisina Acetiltransferases; Apoptose; Proliferação de Células; Ensaios de Seleção de Medicamentos Antitumorais; Histona Acetiltransferases/metabolismo; Histona Acetiltransferases/farmacologia; Histonas/metabolismo; Histonas/farmacologia; Hidrazonas/química; Hidrazonas/farmacologia; Lisina/farmacologia; Lisina Acetiltransferases/metabolismo; Simulação de Acoplamento Molecular; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

CPTH2 analogs; anti-HAT activity; aryl sulfonyl acetophenone; thiazoles; thiosemicarbazone

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lisina Acetiltransferases / Antineoplásicos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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