The CSF in neurosarcoidosis contains consistent clonal expansion of CD8 T cells, but not CD4 T cells.
J Neuroimmunol
; 367: 577860, 2022 06 15.
Article
em En
| MEDLINE
| ID: mdl-35405431
ABSTRACT
The tissue-specific drivers of neurosarcoidosis remain poorly defined. To identify cerebrospinal fluid (CSF) specific, antigen-driven T and B cell responses, we performed single-cell RNA sequencing of CSF and blood cells from neurosarcoid participants coupled to T and B cell receptor sequencing. In contrast to pulmonary sarcoidosis, which is driven by CD4 T cells, we found CD8 T cell clonal expansion enriched in the neurosarcoid CSF. These CSF-enriched CD8 T cells were composed of two subsets with differential expression of EBI2, CXCR3, and CXCR4. Lastly, our data suggest that IFNγ signaling may distinguish neurosarcoidosis from other neurological disorders.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoidose
/
Doenças do Sistema Nervoso Central
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article