Combinations of ATR, Chk1 and Wee1 Inhibitors with Olaparib Are Active in Olaparib Resistant <i>Brca1</i> Proficient and Deficient Murine Ovarian Cells.

Chiappa, Michela; Guffanti, Federica; Anselmi, Martina; Lupi, Monica; Panini, Nicolò; Wiesmüller, Lisa; Damia, Giovanna

Combinations of ATR, Chk1 and Wee1 Inhibitors with Olaparib Are Active in Olaparib Resistant Brca1 Proficient and Deficient Murine Ovarian Cells.

Chiappa, Michela; Guffanti, Federica; Anselmi, Martina; Lupi, Monica; Panini, Nicolò; Wiesmüller, Lisa; Damia, Giovanna.

Afiliação

Chiappa M; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Guffanti F; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Anselmi M; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Lupi M; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Panini N; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.
Wiesmüller L; Department of Obstetrics and Gynecology, Ulm University, 89075 Ulm, Germany.
Damia G; Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, 20156 Milan, Italy.

Cancers (Basel) ; 14(7)2022 Apr 01.

Article em En | MEDLINE | ID: mdl-35406579

Palavras-chave

PARPi; homologous recombination; olaparib resistance; ovarian carcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article