Structure-Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition.

Kim, Jinsoo; Son, Jinyoung; Ahn, Dohee; Nam, Gibeom; Zhao, Xiaodi; Park, Hyuna; Jeong, Woojoo; Chung, Sang J

Kim, Jinsoo; Son, Jinyoung; Ahn, Dohee; Nam, Gibeom; Zhao, Xiaodi; Park, Hyuna; Jeong, Woojoo; Chung, Sang J.

Afiliação

Kim J; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Son J; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Korea.
Ahn D; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Nam G; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Zhao X; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.
Park H; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Korea.
Jeong W; Department of Biopharmaceutical Convergence, Sungkyunkwan University, Suwon 16419, Korea.
Chung SJ; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea.

Int J Mol Sci ; 23(7)2022 Apr 01.

Article em En | MEDLINE | ID: mdl-35409287

Assuntos

Diabetes Mellitus Tipo 2; Resistência à Insulina; Diabetes Mellitus Tipo 2/tratamento farmacológico; Diabetes Mellitus Tipo 2/metabolismo; Glucose/metabolismo; Humanos; Insulina/metabolismo; Fibras Musculares Esqueléticas/metabolismo; Palmitatos/metabolismo; Salicilatos; Transdução de Sinais; Relação Estrutura-Atividade

Palavras-chave

AMPK; Akt; PTPN9 inhibitors; ginkgolic acid analogs; glucose uptake; insulin sensitivity

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistência à Insulina / Diabetes Mellitus Tipo 2 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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