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Associations Between Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants and Risk of Coronavirus Disease 2019 (COVID-19) Hospitalization Among Confirmed Cases in Washington State: A Retrospective Cohort Study.
Paredes, Miguel I; Lunn, Stephanie M; Famulare, Michael; Frisbie, Lauren A; Painter, Ian; Burstein, Roy; Roychoudhury, Pavitra; Xie, Hong; Mohamed Bakhash, Shah A; Perez, Ricardo; Lukes, Maria; Ellis, Sean; Sathees, Saraswathi; Mathias, Patrick C; Greninger, Alexander; Starita, Lea M; Frazar, Chris D; Ryke, Erica; Zhong, Weizhi; Gamboa, Luis; Threlkeld, Machiko; Lee, Jover; McDermot, Evan; Truong, Melissa; Nickerson, Deborah A; Bates, Daniel L; Hartman, Matthew E; Haugen, Eric; Nguyen, Truong N; Richards, Joshua D; Rodriguez, Jacob L; Stamatoyannopoulos, John A; Thorland, Eric; Melly, Geoff; Dykema, Philip E; MacKellar, Drew C; Gray, Hannah K; Singh, Avi; Peterson, JohnAric M; Russell, Denny; Torres, Laura Marcela; Lindquist, Scott; Bedford, Trevor; Allen, Krisandra J; Oltean, Hanna N.
Afiliação
  • Paredes MI; Department of Epidemiology, University of Washington, Seattle, Washington, USA.
  • Lunn SM; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Famulare M; Washington State Department of Health, Shoreline, Washington, USA.
  • Frisbie LA; Institute for Disease Modeling, Bill and Melinda Gates Foundation, Seattle, Washington, USA.
  • Painter I; Washington State Department of Health, Shoreline, Washington, USA.
  • Burstein R; Washington State Department of Health, Shoreline, Washington, USA.
  • Roychoudhury P; Institute for Disease Modeling, Bill and Melinda Gates Foundation, Seattle, Washington, USA.
  • Xie H; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Mohamed Bakhash SA; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Perez R; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Lukes M; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Ellis S; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Sathees S; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Mathias PC; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Greninger A; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Starita LM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Frazar CD; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Ryke E; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
  • Zhong W; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
  • Gamboa L; Brotman Baty Institute for Precision Medicine, Seattle, Washington, USA.
  • Threlkeld M; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
  • Lee J; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
  • McDermot E; Brotman Baty Institute for Precision Medicine, Seattle, Washington, USA.
  • Truong M; Brotman Baty Institute for Precision Medicine, Seattle, Washington, USA.
  • Nickerson DA; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
  • Bates DL; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
  • Hartman ME; Brotman Baty Institute for Precision Medicine, Seattle, Washington, USA.
  • Haugen E; Brotman Baty Institute for Precision Medicine, Seattle, Washington, USA.
  • Nguyen TN; Department of Genome Sciences, University of Washington, Seattle, Washington, USA.
  • Richards JD; Brotman Baty Institute for Precision Medicine, Seattle, Washington, USA.
  • Rodriguez JL; Altius Institute for Biomedical Sciences, Seattle, Washington, USA.
  • Stamatoyannopoulos JA; Altius Institute for Biomedical Sciences, Seattle, Washington, USA.
  • Thorland E; Department of Cardiovascular Services, Swedish Medical Center, Seattle, Washington, USA.
  • Melly G; Altius Institute for Biomedical Sciences, Seattle, Washington, USA.
  • Dykema PE; Altius Institute for Biomedical Sciences, Seattle, Washington, USA.
  • MacKellar DC; Altius Institute for Biomedical Sciences, Seattle, Washington, USA.
  • Gray HK; Altius Institute for Biomedical Sciences, Seattle, Washington, USA.
  • Singh A; Altius Institute for Biomedical Sciences, Seattle, Washington, USA.
  • Peterson JM; Altius Institute for Biomedical Sciences, Seattle, Washington, USA.
  • Russell D; Washington State Department of Health, Shoreline, Washington, USA.
  • Torres LM; Washington State Department of Health, Shoreline, Washington, USA.
  • Lindquist S; Washington State Department of Health, Shoreline, Washington, USA.
  • Bedford T; Washington State Department of Health, Shoreline, Washington, USA.
  • Allen KJ; Washington State Department of Health, Shoreline, Washington, USA.
  • Oltean HN; Washington State Department of Health, Shoreline, Washington, USA.
Clin Infect Dis ; 75(1): e536-e544, 2022 08 24.
Article em En | MEDLINE | ID: mdl-35412591
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic is dominated by variant viruses; the resulting impact on disease severity remains unclear. Using a retrospective cohort study, we assessed the hospitalization risk following infection with 7 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. METHODS: Our study includes individuals with positive SARS-CoV-2 reverse transcription polymerase chain reaction (RT-PCR) in the Washington Disease Reporting System with available viral genome data, from 1 December 2020 to 14 January 2022. The analysis was restricted to cases with specimens collected through sentinel surveillance. Using a Cox proportional hazards model with mixed effects, we estimated hazard ratios (HR) for hospitalization risk following infection with a variant, adjusting for age, sex, calendar week, and vaccination. RESULTS: In total, 58 848 cases were sequenced through sentinel surveillance, of which 1705 (2.9%) were hospitalized due to COVID-19. Higher hospitalization risk was found for infections with Gamma (HR 3.20, 95% confidence interval [CI] 2.40-4.26), Beta (HR 2.85, 95% CI 1.56-5.23), Delta (HR 2.28 95% CI 1.56-3.34), or Alpha (HR 1.64, 95% CI 1.29-2.07) compared to infections with ancestral lineages; Omicron (HR 0.92, 95% CI .56-1.52) showed no significant difference in risk. Following Alpha, Gamma, or Delta infection, unvaccinated patients show higher hospitalization risk, while vaccinated patients show no significant difference in risk, both compared to unvaccinated, ancestral lineage cases. Hospitalization risk following Omicron infection is lower with vaccination. CONCLUSIONS: Infection with Alpha, Gamma, or Delta results in a higher hospitalization risk, with vaccination attenuating that risk. Our findings support hospital preparedness, vaccination, and genomic surveillance.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: America do norte Idioma: En Ano de publicação: 2022 Tipo de documento: Article