Epidermal growth factor receptor signaling in precancerous keratinocytes promotes neighboring head and neck cancer squamous cell carcinoma cancer stem cell-like properties and phosphoinositide 3-kinase inhibitor insensitivity.

Nguyen, Khoa A; Keith, Madison J; Keysar, Stephen B; Hall, Spencer C; Bimali, Anamol; Jimeno, Antonio; Wang, Xiao-Jing; Young, Christian D

Nguyen, Khoa A; Keith, Madison J; Keysar, Stephen B; Hall, Spencer C; Bimali, Anamol; Jimeno, Antonio; Wang, Xiao-Jing; Young, Christian D.

Afiliação

Nguyen KA; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Keith MJ; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Keysar SB; Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Hall SC; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Bimali A; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Jimeno A; Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Wang XJ; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Young CD; Veterans Affairs Medical Center, VA Eastern Colorado Health Care System, Aurora, Colorado, USA.

Mol Carcinog ; 61(7): 664-676, 2022 07.

Article em En | MEDLINE | ID: mdl-35417043

Assuntos

Carcinoma de Células Escamosas; Neoplasias de Cabeça e Pescoço; Lesões Pré-Cancerosas; Carcinoma de Células Escamosas/genética; Linhagem Celular Tumoral; Receptores ErbB/metabolismo; Neoplasias de Cabeça e Pescoço/tratamento farmacológico; Humanos; Queratinócitos/metabolismo; Células-Tronco Neoplásicas/patologia; Fosfatidilinositol 3-Quinase/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Inibidores de Fosfoinositídeo-3 Quinase; Receptores de Fatores de Crescimento de Fibroblastos; Carcinoma de Células Escamosas de Cabeça e Pescoço/tratamento farmacológico; Microambiente Tumoral

Palavras-chave

EGFR; HNSCC; PI3K; cancer stem cell; resistance; squamous cell carcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lesões Pré-Cancerosas / Carcinoma de Células Escamosas / Neoplasias de Cabeça e Pescoço Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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