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Bacterial sensing via neuronal Nod2 regulates appetite and body temperature.
Gabanyi, Ilana; Lepousez, Gabriel; Wheeler, Richard; Vieites-Prado, Alba; Nissant, Antoine; Chevalier, Grégoire; Wagner, Sébastien; Moigneu, Carine; Dulauroy, Sophie; Hicham, Samia; Polomack, Bernadette; Verny, Florine; Rosenstiel, Philip; Renier, Nicolas; Boneca, Ivo Gomperts; Eberl, Gérard; Lledo, Pierre-Marie.
Afiliação
  • Gabanyi I; Institut Pasteur, Université Paris Cité, CNRS UMR 3571, Perception and Memory Unit, F-75015 Paris, France.
  • Lepousez G; Institut Pasteur, Université Paris Cité, INSERM U1224, Microenvironment and Immunity Unit, F-75015 Paris, France.
  • Wheeler R; Institut Pasteur, Université Paris Cité, CNRS UMR 3571, Perception and Memory Unit, F-75015 Paris, France.
  • Vieites-Prado A; Institut Pasteur, Université Paris Cité, CNRS UMR6047, INSERM U1306, Biology and Genetics of the Bacterial Cell Wall Unit, F-75015 Paris, France.
  • Nissant A; Sorbonne Université, Paris Brain Institute-ICM, INSERM U1127, CNRS UMR7225, AP-HP, Hôpital de la Pitié Salpêtrière, F-75013 Paris, France.
  • Chevalier G; Institut Pasteur, Université Paris Cité, CNRS UMR 3571, Perception and Memory Unit, F-75015 Paris, France.
  • Wagner S; Institut Pasteur, Université Paris Cité, INSERM U1224, Microenvironment and Immunity Unit, F-75015 Paris, France.
  • Moigneu C; Institut Pasteur, Université Paris Cité, CNRS UMR 3571, Perception and Memory Unit, F-75015 Paris, France.
  • Dulauroy S; Institut Pasteur, Université Paris Cité, CNRS UMR 3571, Perception and Memory Unit, F-75015 Paris, France.
  • Hicham S; Institut Pasteur, Université Paris Cité, INSERM U1224, Microenvironment and Immunity Unit, F-75015 Paris, France.
  • Polomack B; Institut Pasteur, Université Paris Cité, CNRS UMR6047, INSERM U1306, Biology and Genetics of the Bacterial Cell Wall Unit, F-75015 Paris, France.
  • Verny F; Institut Pasteur, Université Paris Cité, INSERM U1224, Microenvironment and Immunity Unit, F-75015 Paris, France.
  • Rosenstiel P; Sorbonne Université, Paris Brain Institute-ICM, INSERM U1127, CNRS UMR7225, AP-HP, Hôpital de la Pitié Salpêtrière, F-75013 Paris, France.
  • Renier N; Institute of Clinical Molecular Biology, Christian-Albrechts-Universität zu Kiel and University Hospital Schleswig-Holstein, Campus Kiel, 24105 Kiel, Germany.
  • Boneca IG; Sorbonne Université, Paris Brain Institute-ICM, INSERM U1127, CNRS UMR7225, AP-HP, Hôpital de la Pitié Salpêtrière, F-75013 Paris, France.
  • Eberl G; Institut Pasteur, Université Paris Cité, CNRS UMR6047, INSERM U1306, Biology and Genetics of the Bacterial Cell Wall Unit, F-75015 Paris, France.
  • Lledo PM; Institut Pasteur, Université Paris Cité, INSERM U1224, Microenvironment and Immunity Unit, F-75015 Paris, France.
Science ; 376(6590): eabj3986, 2022 04 15.
Article em En | MEDLINE | ID: mdl-35420957
ABSTRACT
Gut bacteria influence brain functions and metabolism. We investigated whether this influence can be mediated by direct sensing of bacterial cell wall components by brain neurons. In mice, we found that bacterial peptidoglycan plays a major role in mediating gut-brain communication via the Nod2 receptor. Peptidoglycan-derived muropeptides reach the brain and alter the activity of a subset of brain neurons that express Nod2. Activation of Nod2 in hypothalamic inhibitory neurons is essential for proper appetite and body temperature control, primarily in females. This study identifies a microbe-sensing mechanism that regulates feeding behavior and host metabolism.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptidoglicano / Proteína Adaptadora de Sinalização NOD2 Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptidoglicano / Proteína Adaptadora de Sinalização NOD2 Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article