Protective role of casuarinin from Melastoma malabathricum against a mouse model of 5-fluorouracil-induced intestinal mucositis: Impact on inflammation and gut microbiota dysbiosis.

Chen, Kung-Ju; Huang, Yu-Ling; Kuo, Liang-Mou; Chen, Yi-Ting; Hung, Chi-Feng; Hsieh, Pei-Wen

Chen, Kung-Ju; Huang, Yu-Ling; Kuo, Liang-Mou; Chen, Yi-Ting; Hung, Chi-Feng; Hsieh, Pei-Wen.

Afiliação

Chen KJ; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan 333, Taiwan.
Huang YL; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan 333, Taiwan.
Kuo LM; Department of General Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
Chen YT; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan 333, Taiwan.
Hung CF; School of Medicine, Fu Jen Catholic University, New Taipei City, Taiwan; Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City, Taiwan.
Hsieh PW; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Natural Products, School of Traditional Chinese Medicine, College of Medicine, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Taoyuan 333, Taiwan; Department of Gene

Phytomedicine ; 101: 154092, 2022 Jul.

Article em En | MEDLINE | ID: mdl-35430483

Assuntos

Gastroenteropatias; Microbioma Gastrointestinal; Enteropatias; Mucosite; Animais; Modelos Animais de Doenças; Disbiose/induzido quimicamente; Disbiose/tratamento farmacológico; Fluoruracila/efeitos adversos; Gastroenteropatias/induzido quimicamente; Humanos; Taninos Hidrolisáveis; Inflamação/metabolismo; Enteropatias/metabolismo; Mucosa Intestinal/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Mucosite/induzido quimicamente; Mucosite/tratamento farmacológico; Mucosite/metabolismo; RNA Ribossômico 16S/genética; Água

Palavras-chave

5-Fluorouracil; Casuarinin; Gut microbiota; Inflammation; Intestinal mucositis; Neutrophil elastase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Mucosite / Microbioma Gastrointestinal / Gastroenteropatias / Enteropatias Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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