CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities.

Kankeu Fonkoua, Lionel A; Sirpilla, Olivia; Sakemura, Reona; Siegler, Elizabeth L; Kenderian, Saad S

CAR T cell therapy and the tumor microenvironment: Current challenges and opportunities.

Kankeu Fonkoua, Lionel A; Sirpilla, Olivia; Sakemura, Reona; Siegler, Elizabeth L; Kenderian, Saad S.

Afiliação

Kankeu Fonkoua LA; T Cell Engineering Laboratory, Mayo Clinic, Rochester, MN, USA.
Sirpilla O; Division of Medical Oncology, Mayo Clinic, Rochester, MN, USA.
Sakemura R; T Cell Engineering Laboratory, Mayo Clinic, Rochester, MN, USA.
Siegler EL; Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA.
Kenderian SS; Department of Molecular Pharmacology & Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.

Mol Ther Oncolytics ; 25: 69-77, 2022 Jun 16.

Article em En | MEDLINE | ID: mdl-35434273

Palavras-chave

chimeric antigen receptor (CAR) T cell therapy; immunosuppression; metabolic fuels; physical barriers; tumor microenvironment

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article