Curcumin activates NLRC4, AIM2, and IFI16 inflammasomes and induces pyroptosis by up-regulated ISG3 transcript factor in acute myeloid leukemia cell lines.

Zhou, Yuru; Kong, Yunyuan; Jiang, Mei; Kuang, Linju; Wan, Jinhua; Liu, Shuyuan; Zhang, Qian; Yu, Kuai; Li, Na; Le, Aiping; Zhang, Zhanglin

Zhou, Yuru; Kong, Yunyuan; Jiang, Mei; Kuang, Linju; Wan, Jinhua; Liu, Shuyuan; Zhang, Qian; Yu, Kuai; Li, Na; Le, Aiping; Zhang, Zhanglin.

Afiliação

Zhou Y; Departments of Blood Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Kong Y; JiangXi Key Laboratory of Transfusion Medicine, Nanchang, Jiangxi, China.
Jiang M; Department of Physical Examination, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Kuang L; Departments of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Wan J; Departments of Blood Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Liu S; Departments of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhang Q; Departments of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Yu K; Departments of Blood Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Li N; JiangXi Key Laboratory of Transfusion Medicine, Nanchang, Jiangxi, China.
Le A; Departments of Blood Transfusion, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Zhang Z; JiangXi Key Laboratory of Transfusion Medicine, Nanchang, Jiangxi, China.

Cancer Biol Ther ; 23(1): 328-335, 2022 12 31.

Article em En | MEDLINE | ID: mdl-35435150

Assuntos

Curcumina; Leucemia Mieloide Aguda; Proteínas Adaptadoras de Sinalização CARD/metabolismo; Proteínas de Ligação ao Cálcio; Curcumina/farmacologia; Proteínas de Ligação a DNA/metabolismo; Humanos; Inflamassomos/metabolismo; Leucemia Mieloide Aguda/tratamento farmacológico; Leucemia Mieloide Aguda/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/genética; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Fosfoproteínas/metabolismo; Piroptose/genética; Células U937

Palavras-chave

Curcumin; GSDMD; inflammasome; leukemia; pyroptosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Curcumina Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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