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Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors.
Cumming, Iain A; Degorce, Sébastien L; Aagaard, Anna; Braybrooke, Erin L; Davies, Nichola L; Diène, Coura R; Eatherton, Andrew J; Felstead, Hannah R; Groombridge, Sam D; Lenz, Eva M; Li, Yunxia; Nai, Youfeng; Pearson, Stuart; Robb, Graeme R; Scott, James S; Steward, Oliver R; Wu, Chengyan; Xue, Yafeng; Zhang, Lanping; Zhang, Yanxiu.
Afiliação
  • Cumming IA; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom. Electronic address: iain.cumming@astrazeneca.com.
  • Degorce SL; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Aagaard A; Discovery Sciences, R&D, AstraZeneca, Gothenburg, SE-431 83 Mölndal, Sweden.
  • Braybrooke EL; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Davies NL; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Diène CR; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Eatherton AJ; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Felstead HR; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Groombridge SD; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Lenz EM; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Li Y; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176 PR China.
  • Nai Y; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176 PR China.
  • Pearson S; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Robb GR; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Scott JS; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Steward OR; Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Cambridge Science Park, Unit 310 Darwin Building, Cambridge CB4 0WG, United Kingdom.
  • Wu C; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176 PR China.
  • Xue Y; Discovery Sciences, R&D, AstraZeneca, Gothenburg, SE-431 83 Mölndal, Sweden.
  • Zhang L; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176 PR China.
  • Zhang Y; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176 PR China.
Bioorg Med Chem ; 63: 116729, 2022 06 01.
Article em En | MEDLINE | ID: mdl-35439688
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Quinases Associadas a Receptores de Interleucina-1 Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridonas / Quinases Associadas a Receptores de Interleucina-1 Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article