Pharmacodynamic evaluation of the XOR inhibitor WN1703 in a model of chronic hyperuricemia in rats induced by yeast extract combined with potassium oxonate.

Li, Yuanyuan; Zhu, Xinying; Liu, Fuyao; Peng, Wen; Zhang, Lei; Li, Jing

Li, Yuanyuan; Zhu, Xinying; Liu, Fuyao; Peng, Wen; Zhang, Lei; Li, Jing.

Afiliação

Li Y; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.
Zhu X; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.
Liu F; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.
Peng W; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.
Zhang L; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.
Li J; MOE International Joint Research Laboratory on Synthetic Biology and Medicines, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China.

Curr Res Pharmacol Drug Discov ; 3: 100098, 2022.

Article em En | MEDLINE | ID: mdl-35465446

Palavras-chave

ADA, adenosine deaminase; BUN, blood urea nitrogen; CG, control group; CMC-Na, sodium carboxymethyl cellulose; FEB, febuxostat; Febuxostat; GSH-PX, glutathione peroxidase; H1703, high dose of WN1703; Hyperuricemia; IL-1ß, interleukin-1ß; L1703, low dose of WN1703; M1703, median dose of WN1703; MCP, monocyte chemoattractant protein; MG, model group; Rat model; TNF-α, tumor necrosis factor-α; UA, uric acid; URAT1, urate transport protein 1; Uric acid; XOR inhibitor; XOR, xanthine oxidoreductase; YEP, yeast extract paste

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article