Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment.

Xu, Alan; Yang, Ruoxi; Zhang, Mingfei; Wang, Xiang; Di, Yuxi; Jiang, Baoping; Di, Yongxiang; Zhou, Zhanwei; Zhou, Lingling

Xu, Alan; Yang, Ruoxi; Zhang, Mingfei; Wang, Xiang; Di, Yuxi; Jiang, Baoping; Di, Yongxiang; Zhou, Zhanwei; Zhou, Lingling.

Afiliação

Xu A; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Yang R; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China.
Zhang M; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Wang X; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Di Y; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Jiang B; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.
Di Y; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China.
Zhou Z; Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, PR China.
Zhou L; Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, PR China.

J Drug Target ; 30(9): 961-972, 2022 11.

Article em En | MEDLINE | ID: mdl-35467469

Assuntos

Artrite Reumatoide; Micelas; Anti-Inflamatórios/uso terapêutico; Artrite Reumatoide/tratamento farmacológico; Artrite Reumatoide/metabolismo; Citocinas/metabolismo; Dextranos/metabolismo; Dextranos/uso terapêutico; Diterpenos; Compostos de Epóxi; Ácido Fólico/metabolismo; Humanos; Imunossupressores/metabolismo; Imunossupressores/uso terapêutico; Interleucina-6/metabolismo; Macrófagos/metabolismo; Nucleotidiltransferases/metabolismo; Nucleotidiltransferases/uso terapêutico; Fenantrenos; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

Triptolide; cGAS-STING; micelles; rheumatoid arthritis; targeted delivery

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Micelas Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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