Stereochemical switch driven by crystallization: Interplay between stoichiometry and configuration of the products.
Chirality
; 34(7): 948-954, 2022 07.
Article
em En
| MEDLINE
| ID: mdl-35470504
ABSTRACT
An intriguing example of a crystallization-induced stereochemical switch in the configuration of aza-Michael reaction products is described. Depending on both the stereochemical purity and stoichiometric ratio of the chiral amine used, the reaction delivers crystalline diastereomers of a different stereochemistry. The optically pure diastereomer smoothly converts to its racemic epimer salt upon the addition of a complementary chiral amine.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminas
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article