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Increased LCN2 (lipocalin 2) in the RPE decreases autophagy and activates inflammasome-ferroptosis processes in a mouse model of dry AMD.
Gupta, Urvi; Ghosh, Sayan; Wallace, Callen T; Shang, Peng; Xin, Ying; Nair, Archana Padmanabhan; Yazdankhah, Meysam; Strizhakova, Anastasia; Ross, Mark A; Liu, Haitao; Hose, Stacey; Stepicheva, Nadezda A; Chowdhury, Olivia; Nemani, Mihir; Maddipatla, Vishnu; Grebe, Rhonda; Das, Manjula; Lathrop, Kira L; Sahel, José-Alain; Zigler, J Samuel; Qian, Jiang; Ghosh, Arkasubhra; Sergeev, Yuri; Handa, James T; St Croix, Claudette M; Sinha, Debasish.
Afiliação
  • Gupta U; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Ghosh S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Wallace CT; Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Shang P; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Xin Y; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Nair AP; GROW Laboratory, Narayana Nethralaya Foundation, Bengaluru, India.
  • Yazdankhah M; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Strizhakova A; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Ross MA; Department of Cell Biology and Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Liu H; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Hose S; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Stepicheva NA; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Chowdhury O; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Nemani M; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Maddipatla V; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Grebe R; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Das M; Molecular Immunology, Mazumdar Shaw Medical Foundation, Bengaluru, India.
  • Lathrop KL; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Sahel JA; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, PA, USA.
  • Zigler JS; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
  • Qian J; Institut De La Vision, INSERM, CNRS, Sorbonne Université, Paris, France.
  • Ghosh A; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Sergeev Y; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Handa JT; GROW Laboratory, Narayana Nethralaya Foundation, Bengaluru, India.
  • St Croix CM; National Eye Institute, National Institutes of Health, Bethesda, MD, USA.
  • Sinha D; Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Autophagy ; 19(1): 92-111, 2023 01.
Article em En | MEDLINE | ID: mdl-35473441
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ferroptose / Degeneração Macular Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ferroptose / Degeneração Macular Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article